Cryo-EM structure of SNAP-94847-bound MCHR1, S1 state
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8yns
Q-score: 0.476
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
Cryo-EM structure of SNAP-94847-bound MCHR1, S2 state
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8ynt
Q-score: 0.422
Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W
Cell Discov (2024) 10 pp. 124-124 [ DOI: doi:10.1038/s41421-024-00754-0 Pubmed: 39616153 ]
- Glue molecule 4-9 (30 kDa, Protein from synthetic construct)
- Snap-94847-mchr1-fab1b3-glue complex (Complex from Homo sapiens)
- Melanin-concentrating hormone receptor 1,soluble cytochrome b562 (64 kDa, Protein from Homo sapiens)
- Antibody 1b3 fab light chain (23 kDa, Protein from synthetic construct)
- Antibody 1b3 fab heavy chain (25 kDa, Protein from synthetic construct)
- ~{n}-[3-[1-[[4-[3,4-bis(fluoranyl)phenoxy]phenyl]methyl]piperidin-4-yl]-4-methyl-phenyl]-2-methyl-propanamide (478 Da, Ligand)
EB-bound E46K alpha-synuclein fibrils
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
PNAS (2024) 121 pp. e2321633121-e2321633121 [ Pubmed: 39172784 DOI: doi:10.1073/pnas.2321633121 ]
- Eb-bound e46k alpha-synuclein fibril (Complex from Homo sapiens)
- 4-azanyl-6-[[4-[4-[(~{e})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid (872 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
CR-bound E46K alpha-synuclein fibrils
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8x7m
Q-score: 0.115
PiB-bound E46K mutanted alpha-synuclein fibrils
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8x7o
Q-score: 0.464
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
PNAS (2024) 121 pp. e2321633121-e2321633121 [ Pubmed: 39172784 DOI: doi:10.1073/pnas.2321633121 ]
- Pib-bound e46k mutated alpha-synuclein fibril (Complex from Homo sapiens)
- 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol (256 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
BTA-2-bound E46K alpha-synuclein fibrils
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8zli
Q-score: 0.464
F0502B-bound E46K alpha-synuclein fibril
Resolution: 3.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 8zlo
Q-score: 0.478
apo WT polymorph 5a alpha-synuclein fibril
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
PNAS (2024) 121 pp. e2321633121-e2321633121 [ Pubmed: 39172784 DOI: doi:10.1073/pnas.2321633121 ]
- Alpha-synuclein (9 kDa, Protein from Homo sapiens)
- Apo wt polymorph 5a alpha-synuclein fibril (Complex from Homo sapiens)