human KCNQ2-CaM-Ebio1 complex in the presence of PIP2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ijk
Q-score: 0.383
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ DOI: doi:10.1038/s41589-023-01515-y Pubmed: 38167918 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1 complex in the presence of pip2 (Complex from Homo sapiens)
- N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (291 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8x43
Q-score: 0.328
Zhang S, Ma D, Wang K, Li Y, Yang Z, Li X, Li J, He J, Mei L, Ye Y, Chen Z, Shen J, Hou P, Guo J, Zhang Q, Yang H
Nat Chem Biol (2024) 20 pp. 847-856 [ DOI: doi:10.1038/s41589-023-01515-y Pubmed: 38167918 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-ebio1-s1 complex in the presence of pip2 (Cellular component from Homo sapiens)
- N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (306 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
Human KCNQ2-CaM in complex with CBD and PIP2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j01
Q-score: 0.421
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Human kcnq2-cam in complex with cbd and pip2 (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8j02
Q-score: 0.348
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Human kcnq2(f104a)-cam-pip2-cbd complex in state ii (Complex from Homo sapiens)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
human KCNQ2-CaM in complex with PIP2 and HN37
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w4u
Q-score: 0.354
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Calmodulin-1 (16 kDa, Protein from Homo sapiens)
- Methyl n-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate (340 Da, Ligand)
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with pip2 and hn37 (Cellular component from Homo sapiens)
Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j03
Q-score: 0.358
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2(f104a)-cam-pip2-cbd complex in state i (Complex from Homo sapiens)
Human KCNQ2-CaM-HN37 complex in the presence of PIP2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j04
Q-score: 0.329
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Methyl n-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate (340 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam-hn37 complex in the presence of pip2 (Complex from Homo sapiens)
Human KCNQ2-CaM complex in the presence of PIP2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j05
Q-score: 0.343
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Human kcnq2-cam complex in the presence of pip2 (Complex from Homo sapiens)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
Human KCNQ2-CaM in complex with HN37
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8izy
Q-score: 0.529
Human KCNQ2-CaM in complex with CBD
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8j00
Q-score: 0.387
Ma D, Zheng Y, Li X, Zhou X, Yang Z, Zhang Y, Wang L, Zhang W, Fang J, Zhao G, Hou P, Nan F, Yang W, Su N, Gao Z, Guo J
Nat Commun (2023) 14 pp. 6632-6632 [ DOI: doi:10.1038/s41467-023-42416-x Pubmed: 37857637 ]
- Potassium voltage-gated channel subfamily kqt member 2 (73 kDa, Protein from Homo sapiens)
- Cannabidiol (314 Da, Ligand)
- Calmodulin-1 (19 kDa, Protein from Homo sapiens)
- Human kcnq2-cam in complex with cbd (Complex from Homo sapiens)