Structure of mouse Myomaker bound to Fab18G7 in detergent
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8t03
Q-score: 0.574
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- Mouse myomaker (Complex from Mus musculus)
- Complex of mouse myomaker and fab18g7 (Complex)
- Cholesterol (386 Da, Ligand)
- Fab18g7 (Complex from Mus musculus)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
Structure of mouse Myomaker bound to Fab18G7 in nanodiscs
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8t04
Q-score: 0.528
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Complex of mouse myomaker with fab18g7 in nanodiscs (Complex)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- Mouse myomaker (Complex from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Fab18g7 (Complex from Mus musculus)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
Structure of Ciona Myomaker bound to Fab1A1
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8t05
Q-score: 0.497
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Ciona robusta myomaker (Complex from Ciona robusta)
- 1a1 fab heavy chain (13 kDa, Protein from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Complex of ciona robusta myomaker with fab1a1 (Complex)
- Fab1a1 (Complex from Mus musculus)
- Myomaker (24 kDa, Protein from Ciona robusta)
- 1a1 fab light chain (11 kDa, Protein from Mus musculus)
Structure of mouse Myomaker mutant-R107A bound to Fab18G7
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8t06
Q-score: 0.479
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Mouse myomaker mutant-r107a (Complex from Mus musculus)
- Complex of mouse myomaker mutant-r107a with fab18g7 (Complex)
- Fab18g7 (Complex from Mus musculus)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
Structure of mouse Myomaker mutant-Y118A bound to Fab18G7
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8t07
Q-score: 0.47
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X
Nat Struct Mol Biol (2023) 30 pp. 1746-1754 [ Pubmed: 37770716 DOI: doi:10.1038/s41594-023-01110-8 ]
- Mouse myomaker mutant-y118a (Complex from Mus musculus)
- Fab18g7 (Complex from Mus musculus)
- Complex of mouse myomaker mutant-y118a with fab18g7 (Complex)
- Protein myomaker (24 kDa, Protein from Mus musculus)
- 18g7 fab heavy chain (13 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 18g7 fab light chain (11 kDa, Protein from Mus musculus)
Human PORCN in complex with Palmitoleoyl-CoA
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7ura
Q-score: 0.557
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{z})-hexadec-9-enethioate (1 kDa, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- 16:1 coa-bound human porcn (Complex)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Digitonin (1 kDa, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7urc
Q-score: 0.532
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Lgk974-bound human porcn (Complex)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7urd
Q-score: 0.569
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- Isoform 2 of protein wnt-3a peptide (2 kDa, Protein from Homo sapiens)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- Lgk974 and wnt3a peptide-bound human porcn (Complex)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Isoform 2 of protein wnt-3a peptide (Complex)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Digitonin (1 kDa, Ligand)
Human PORCN in complex with palmitoleoylated WNT3A peptide
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7ure
Q-score: 0.539
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- Protein wnt-3a (2 kDa, Protein from Homo sapiens)
- Palmitoleic acid (254 Da, Ligand)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of protein wnt-3a (Complex)
- Product-bound human porcn (Complex)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Digitonin (1 kDa, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7urf
Q-score: 0.597
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- 3h02 heavy chain, 3h02 light chain (Complex from Mus musculus)
- 3h02 heavy chain (27 kDa, Protein from Mus musculus)
- 3h02 light chain (26 kDa, Protein from Mus musculus)
- 16:0 coa and shh-n-bound human hhat (Complex)
- Protein-cysteine n-palmitoyltransferase hhat (e.c.2.3.1.-), shh-n peptide (Complex from Homo sapiens)
- Protein-cysteine n-palmitoyltransferase hhat (58 kDa, Protein from Homo sapiens)
- Shh-n peptide (693 Da, Protein from Homo sapiens)
- Digitonin (1 kDa, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Palmitoyl-coa (1 kDa, Ligand)