Human VMAT2 in complex with tetrabenazine
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8t69
Q-score: 0.558
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
- Tetrabenazine (317 Da, Ligand)
- Human vmat2 in complex with tetrabenazine (Complex from Homo sapiens)
Human VMAT2 in complex with reserpine
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8t6a
Q-score: 0.504
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Reserpine (608 Da, Ligand)
- Human vmat2 in complex with reserpine (Complex from Homo sapiens)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
Human VMAT2 in complex with serotonin
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8t6b
Q-score: 0.39
Pidathala S, Liao S, Dai Y, Li X, Long C, Chang CL, Zhang Z, Lee CH
Nature (2023) 623 pp. 1086-1092 [ Pubmed: 37914936 DOI: doi:10.1038/s41586-023-06727-9 ]
- Serotonin (176 Da, Ligand)
- Human vmat2 in complex with serotonin (Complex from Homo sapiens)
- Synaptic vesicular amine transporter (53 kDa, Protein from Homo sapiens)
Human S1P transporter Spns2 in an inward-facing open conformation (state 1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8ex4
Q-score: 0.558
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing open conformation (state 4)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8ex5
Q-score: 0.422
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an inward-facing open conformation (state 1*)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8ex6
Q-score: 0.485
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 3)
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8ex7
Q-score: 0.458
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Human S1P transporter Spns2 in an outward-facing partially occluded conformation (state 2)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 8ex8
Q-score: 0.35
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644- [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
Structure of inhibitor 16d-bound SPNS2
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8g92
Q-score: 0.454
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH
Cell (2023) 186 pp. 2644-2655.e16 [ Pubmed: 37224812 DOI: doi:10.1016/j.cell.2023.04.028 ]
- Spns2 in complex with inhibitor 16d (200 kDa, Complex from Homo sapiens)
- 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine (343 Da, Ligand)
- Sphingosine-1-phosphate transporter spns2 (49 kDa, Protein from Homo sapiens)