Curved structure of mPIEZO1-S2472E
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 8ixn
Q-score: 0.301
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ DOI: doi:10.1016/j.neuron.2024.11.020 Pubmed: 39719701 ]
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- S2472e-curved structure (Complex from Mus musculus)
Flattened structure of mPIEZO1-S2472E
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ixo
Q-score: 0.445
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ DOI: doi:10.1016/j.neuron.2024.11.020 Pubmed: 39719701 ]
- S2472e-intermediate structure (Complex from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6lqi
Q-score: 0.326
Geng J, Liu W, Zhou H, Zhang T, Wang L, Zhang M, Li Y, Shen B, Li X, Xiao B
Neuron (2020) 106 pp. 438- [ DOI: doi:10.1016/j.neuron.2020.02.010 Pubmed: 32142647 ]
- Homo-trimer of piezo1.1 (880 kDa, Complex from Mus musculus)
- Piezo-type mechanosensitive ion channel component 1 (289 kDa, Protein from Mus musculus)
Resolution: 1.5 Å
EM Method: Electron Crystallography
Fitted PDBs: 6law
Q-score: 0.894
J Struct Biol (2019) 205 pp. 59-64 [ DOI: doi:10.1016/j.jsb.2019.02.004 Pubmed: 30794865 ]
- Proteinase k (28 kDa, Protein from Parengyodontium album)
- Sulfate ion (96 Da, Ligand)
- Water (18 Da, Ligand)
- Proteinase k (Complex from Parengyodontium album)
Resolution: 1.73 Å
EM Method: Electron Crystallography
Fitted PDBs: 6lav
Q-score: 0.811
J Struct Biol (2019) 205 pp. 59-64 [ DOI: doi:10.1016/j.jsb.2019.02.004 Pubmed: 30794865 ]
- Acetate ion (59 Da, Ligand)
- Water (18 Da, Ligand)
- Lysozyme (Complex from Gallus gallu)
- Lysozyme c (14 kDa, Protein from Gallus gallus)
Cryo-EM Structure of the Mammalian Tactile Channel Piezo2
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6kg7
Q-score: 0.437
Wang L, Zhou H, Zhang M, Liu W, Deng T, Zhao Q, Li Y, Lei J, Li X, Xiao B
Nature (2019) 573 pp. 225-229 [ DOI: doi:10.1038/s41586-019-1505-8 Pubmed: 31435011 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Piezo-type mechanosensitive ion channel component 2 (325 kDa, Protein from Mus musculus)
- Homo-trimer of piezo2 (1 MDa, Complex from Mus musculus)