Structure of 26RFa-pyroglutamylated RFamide peptide receptor complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8wz2
Q-score: 0.45
Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y
Cell Discov (2024) 10 pp. 58-58 [ DOI: doi:10.1038/s41421-024-00670-3 Pubmed: 38830850 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Structure of 26rfa-pyroglutamylated rfamide peptide receptor-g protein complex (160 kDa, Complex from Homo sapiens)
- Pyroglutamylated rf-amide peptide receptor (49 kDa, Protein from Homo sapiens)
- G-alpha q (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Orexigenic neuropeptide qrfp (2 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpb
Q-score: 0.448
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- Ntsr1-grk2-galpha(q) complexes 1 (Complex from Homo sapiens)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpc
Q-score: 0.458
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Ntsr1-grk2-galpha(q) complexes 2 (Complex from Homo sapiens)
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8jpd
Q-score: 0.497
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ DOI: doi:10.1038/s41586-023-06395-9 Pubmed: 37532940 ]
- Staurosporine (466 Da, Ligand)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Focused refinement structure of grk2 in ntsr1-grk2-galpha(q) complexes (Complex from Bos taurus)
The V1 region of bovine V-ATPase in complex with human mEAK7 (focused refinement)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7une
Q-score: 0.496
Nat Commun (2022) 13 pp. 3272-3272 [ Pubmed: 35672408 DOI: doi:10.1038/s41467-022-30899-z ]
- Cryo-em structure of the v1 region of bovine v-atpase in complex with human meak7 (Complex from Bos taurus)
- Kiaa1609 protein, isoform cra_a (51 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d (28 kDa, Protein from Bos taurus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Bos taurus)
- V-type proton atpase subunit g (13 kDa, Protein from Bos taurus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Bos taurus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Bos taurus)
Melatonin receptor1-2-Iodomelatonin-Gicomplex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7vgy
Q-score: 0.508
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ DOI: doi:10.1038/s41467-022-28111-3 Pubmed: 35075127 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- G protein coupled to melatonin receptor (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
- N-[2-(2-iodo-5-methoxy-1h-indol-3-yl)ethyl]acetamide (358 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vgz
Q-score: 0.473
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl}propanamide (259 Da, Ligand)
- Gpcr-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of bafilomycin A1-bound intact V-ATPase from bovine brain
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 7khr
Q-score: 0.493
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X
Nat Commun (2021) 12 pp. 1782-1782 [ DOI: doi:10.1038/s41467-021-22111-5 Pubmed: 33741963 ]
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Bos taurus)
- V-type proton atpase subunit h (54 kDa, Protein from Bos taurus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Bos taurus)
- Cryo-em structure of bafilomycin a1-bound intact v-atpase from bovine brain (Complex from Bos taurus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Bos taurus)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d (28 kDa, Protein from Bos taurus)
- (5r)-2,4-dideoxy-1-c-{(2s,3r,4s)-3-hydroxy-4-[(2r,3s,4e,6e,9r,10s,11r,12e,14z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl}-4-methyl-5-propan-2-yl-alpha-d-threo-pentopyranose (622 Da, Ligand)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Bos taurus)
- Renin receptor (39 kDa, Protein from Bos taurus)
- Methyl (3r,6z,10e,14e)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate (534 Da, Ligand)
- V-type proton atpase subunit f (13 kDa, Protein from Bos taurus)
- Oleic acid (282 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase subunit c 1 (44 kDa, Protein from Bos taurus)
- V-type proton atpase subunit s1 (51 kDa, Protein from Bos taurus)
- V-type proton atpase subunit a (96 kDa, Protein from Bos taurus)
- V-type proton atpase subunit e 2 (9 kDa, Protein from Bos taurus)
- V-type proton atpase subunit g (13 kDa, Protein from Bos taurus)
- Ribonuclease kappa (11 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of V-ATPase from bovine brain, state 1
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 6xbw
Q-score: 0.479
Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X
Nat Commun (2020) 11 pp. 3921-3921 [ Pubmed: 32764564 DOI: doi:10.1038/s41467-020-17762-9 ]
- V-type proton atpase subunit e 2 (9 kDa, Protein from Bos taurus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- V-type proton atpase subunit s1 (51 kDa, Protein from Bos taurus)
- V-type proton atpase subunit h (54 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ribonuclease kappa (11 kDa, Protein from Bos taurus)
- V-type proton atpase subunit f (13 kDa, Protein from Bos taurus)
- V-type proton atpase subunit g (13 kDa, Protein from Bos taurus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Bos taurus)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Bos taurus)
- V-type proton atpase subunit c 1 (44 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Bos taurus)
- Oleic acid (282 Da, Ligand)
- Renin receptor (39 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d (28 kDa, Protein from Bos taurus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- V-type proton atpase subunit a (96 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Bos taurus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Bos taurus)
- Cryo-em structure of v-atpase complex from bovine brain, state 1 (Complex from Bos taurus)
Cryo-EM structure of V-ATPase from bovine brain, state 2
Resolution: 3.79 Å
EM Method: Single-particle
Fitted PDBs: 6xby
Q-score: 0.432
Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X
Nat Commun (2020) 11 pp. 3921-3921 [ Pubmed: 32764564 DOI: doi:10.1038/s41467-020-17762-9 ]
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- V-type proton atpase subunit s1 (51 kDa, Protein from Bos taurus)
- V-type proton atpase subunit h (54 kDa, Protein from Bos taurus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of v-atpase complex from bovine brain, state 2 (Complex from Bos taurus)
- V-type proton atpase subunit f (13 kDa, Protein from Bos taurus)
- V-type proton atpase subunit g (13 kDa, Protein from Bos taurus)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Bos taurus)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Bos taurus)
- V-type proton atpase subunit c 1 (44 kDa, Protein from Bos taurus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Bos taurus)
- Renin receptor (39 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d (28 kDa, Protein from Bos taurus)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- V-type proton atpase subunit a (96 kDa, Protein from Bos taurus)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Bos taurus)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Bos taurus)