Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP)
Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J
Nature (2025) [ DOI: doi:10.1038/s41586-024-08521-7 ]
- Probable disease resistance protein at5g66900 (46 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Protein eds1 (70 kDa, Protein from Arabidopsis thaliana)
- Ternary complex of nrg1a(lrr) with eds1-sag101-(adpr-atp) (Complex from Arabidopsis)
- Senescence-associated carboxylesterase 101 (61 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement)
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7yhw
Q-score: 0.516
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 omicron ba.2.12.1 rbd in complex with human ace2 (local refinement) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ace2 (Complex)
- Omicron ba.2.12.1 rbd (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7yj3
Q-score: 0.468
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Omicron ba.2 rbd (Complex)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with human ace2 (local refinement) (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 7yv8
Q-score: 0.553
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with golden hamster ace2 (local refinement) (Complex)
- Omicron ba.2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme (68 kDa, Protein from Mesocricetus auratus)
- Spike glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Golden hamster angiotensin-converting enzyme 2 (Complex from Mesocricetus auratus)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with mouse ACE2 (local refinement)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7yvu
Q-score: 0.484
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Omicron ba.2 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mouse angiotensin-converting enzyme 2 (Complex from Mus musculus)
- Processed angiotensin-converting enzyme 2 (68 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with mouse ace2 (local refinement) (Complex)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with rat ACE2 (local refinement)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8gry
Q-score: 0.425
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Cryo-em structure of sars-cov-2 omicron ba.2 rbd in complex with mouse ace2 (local refinement) (Complex from Rattus norvegicus)
- Rat angiotensin-converting enzyme 2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Omicron ba.2 rbd (Complex)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 RBD in complex with human ACE2 (local refinement)
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8h06
Q-score: 0.566
Zhao Z, Xie Y, Bai B, Luo C, Zhou J, Li W, Meng Y, Li L, Li D, Li X, Li X, Wang X, Sun J, Xu Z, Sun Y, Zhang W, Fan Z, Zhao X, Wu L, Ma J, Li OY, Shang G, Chai Y, Liu K, Wang P, Gao GF, Qi J
Nat Commun (2023) 14 pp. 4405-4405 [ DOI: doi:10.1038/s41467-023-39942-z Pubmed: 37479708 ]
- Omicron ba.4/5 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme 2 (Complex from Homo sapiens)
- Cryo-em structure of sars-cov-2 omicron ba.4/5 rbd in complex with human ace2 (local refinement) (Complex)
Human PORCN in complex with Palmitoleoyl-CoA
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7ura
Q-score: 0.557
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- Cholesterol (386 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Digitonin (1 kDa, Ligand)
- Zinc ion (65 Da, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{z})-hexadec-9-enethioate (1 kDa, Ligand)
- 16:1 coa-bound human porcn (Complex)
- Oleic acid (282 Da, Ligand)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7urc
Q-score: 0.532
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- Digitonin (1 kDa, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Lgk974-bound human porcn (Complex)
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7urd
Q-score: 0.569
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X
Nature (2022) 607 pp. 816-822 [ Pubmed: 35831507 DOI: doi:10.1038/s41586-022-04952-2 ]
- Isoform 2 of protein wnt-3a peptide (2 kDa, Protein from Homo sapiens)
- 2c11 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (52 kDa, Protein from Homo sapiens)
- Isoform 2 of protein-serine o-palmitoleoyltransferase porcupine (e.c.2.3.1.250) (Complex from Homo sapiens)
- Lgk974 and wnt3a peptide-bound human porcn (Complex)
- 2c11 light chain (25 kDa, Protein from Mus musculus)
- Cholesterol (386 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Isoform 2 of protein wnt-3a peptide (Complex)
- 2-[(2p)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-n-[(5p)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide (396 Da, Ligand)
- 2c11 light chain, 2c11 heavy chain (Complex from Mus musculus)
- Zinc ion (65 Da, Ligand)
- Digitonin (1 kDa, Ligand)