Curved structure of mPIEZO1-S2472E
Resolution: 4.07 Å
EM Method: Single-particle
Fitted PDBs: 8ixn
Q-score: 0.301
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- S2472e-curved structure (Complex from Mus musculus)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Flattened structure of mPIEZO1-S2472E
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ixo
Q-score: 0.445
Liu S, Yang X, Chen X, Zhang X, Jiang J, Yuan J, Liu W, Wang L, Zhou H, Wu K, Tian B, Li X, Xiao B
Neuron (2024) [ Pubmed: 39719701 DOI: doi:10.1016/j.neuron.2024.11.020 ]
- Piezo-type mechanosensitive ion channel component 1 (292 kDa, Protein from Mus musculus)
- S2472e-intermediate structure (Complex from Mus musculus)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- (9r,11s)-9-({[(1s)-1-hydroxyhexadecyl]oxy}methyl)-2,2-dimethyl-5,7,10-trioxa-2lambda~5~-aza-6lambda~5~-phosphaoctacosane-6,6,11-triol (767 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8vh4
Q-score: 0.333
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ DOI: doi:10.1038/s41467-024-52723-6 Pubmed: 39343966 ]
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8vh5
Q-score: 0.248
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ DOI: doi:10.1038/s41467-024-52723-6 Pubmed: 39343966 ]
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
Vgamma5Vdelta1 EH TCR-CD3 complex
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8wxe
Q-score: 0.329
Xin W, Huang B, Chi X, Liu Y, Xu M, Zhang Y, Li X, Su Q, Zhou Q
Nature (2024) 630 pp. 222-229 [ DOI: doi:10.1038/s41586-024-07439-4 Pubmed: 38657677 ]
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- Signal peptide,flag tag,t cell receptor gamma variable 5,t cell receptor gamma constant 1 (37 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (18 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- Signal peptide,flag tag,t cell receptor delta variable 1,t cell receptor delta constant (34 kDa, Protein from Homo sapiens)
- T cell receptor delta 1 gamma 5 eh mutant (Complex from Homo sapiens)
- T-cell surface glycoprotein cd3 zeta chain (21 kDa, Protein from Homo sapiens)
T cell receptor V delta2 V gamma9 in GDN
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8yc0
Q-score: 0.349
Xin W, Huang B, Chi X, Liu Y, Xu M, Zhang Y, Li X, Su Q, Zhou Q
Nature (2024) 630 pp. 222-229 [ DOI: doi:10.1038/s41586-024-07439-4 Pubmed: 38657677 ]
- Cholesterol (386 Da, Ligand)
- Tcr v delta2 v gamma 9 in complex with cd3 in gdn (Cell from Homo sapiens)
- T-cell surface glycoprotein cd3 delta chain (18 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 epsilon chain (23 kDa, Protein from Homo sapiens)
- T cell receptor gamma variable 9,t cell receptor gamma constant 1 (37 kDa, Protein from Homo sapiens)
- T cell receptor delta variable 2,t cell receptor delta constant (34 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 gamma chain (20 kDa, Protein from Homo sapiens)
- T-cell surface glycoprotein cd3 zeta chain (21 kDa, Protein from Homo sapiens)
CryoEM structure of a mEAK7 bound human V-ATPase complex
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 7unf
Q-score: 0.479
Nat Commun (2022) 13 pp. 3272-3272 [ DOI: doi:10.1038/s41467-022-30899-z Pubmed: 35672408 ]
- V-type proton atpase subunit g 1 (13 kDa, Protein from Homo sapiens)
- Ribonuclease kappa (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit e 1 (26 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit c 1 (43 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- V-type proton atpase 21 kda proteolipid subunit (21 kDa, Protein from Homo sapiens)
- Cryoem structure of meak7 bound human v-atpase complex (Complex from Homo sapiens)
- V-type proton atpase 116 kda subunit a 4 (98 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d 1 (40 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit b, brain isoform (56 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit d (28 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit s1 (52 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- V-type proton atpase catalytic subunit a (68 kDa, Protein from Homo sapiens)
- V-type proton atpase 16 kda proteolipid subunit (15 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit f (13 kDa, Protein from Homo sapiens)
- V-type proton atpase subunit h (55 kDa, Protein from Homo sapiens)
- Atpase h(+)-transporting lysosomal accessory protein 2 (38 kDa, Protein from Homo sapiens)
- Kiaa1609 protein, isoform cra_a (51 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- V-type proton atpase subunit e 1 (9 kDa, Protein from Homo sapiens)
Dicer2-LoqsPD-dsRNA complex at mid-translocation state
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 7w0d
Q-score: 0.318
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Dicer2-loqspd-dsrna complex at its mid-translocation state (Complex from Drosophila melanogaster)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Dsrna (16 kDa, RNA from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
dmDicer2-LoqsPD-dsRNA Active-dicing status
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 7w0e
Q-score: 0.366
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Dicer2-loqspd-dsrna complex at its active-dicing state (Complex from Drosophila melanogaster)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Dsrna (16 kDa, RNA from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n28
Q-score: 0.385
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ Pubmed: 35319830 DOI: doi:10.1002/advs.202200063 ]
- J033 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- Alpha-d-mannopyranose (180 Da, Ligand)
- J033 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (19 kDa, Protein from Human immunodeficiency virus 1)
- Phosphate ion (94 Da, Ligand)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A complex of hiv-1 env with antibodies 3bnc117 and j033 (Complex from Homo sapiens)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)