Structure of C5a-pep bound mouse C5aR1 in complex with Go
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8hpt
Q-score: 0.491
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Mea-lys-pro-zal-alc-dar (869 Da, Protein from synthetic construct)
- Antibody fragment (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Synthetic peptide (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gpcr-g protein in complex with a synthetic peptide agonist (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of a GPCR-G protein in complex with a natural peptide agonist
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8hqc
Q-score: 0.443
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Antibody fragment (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpcr-g protein in complex with a natural peptide agonist (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Antibody fragment (Complex from Mus musculus)
- C5a anaphylatoxin (Complex from Homo sapiens)
Structure of EP54-C3aR-Go complex
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8i95
Q-score: 0.561
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- Structure of ep54-c3ar-go complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Ep54 ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of Apo-C3aR-Go complex (Glacios)
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8i97
Q-score: 0.5
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Structure of apo-c3ar-go complex (glacios) (Complex)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of EP54-C3aR-Gq complex
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8i9a
Q-score: 0.431
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Ep54 ligand (1 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Ep54 ligand (Complex from Homo sapiens)
- Structure of ep54-c3ar-gq complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (Complex from Homo sapiens)
Structure of C3a-C3aR-Go complex (Composite map)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8i9l
Q-score: 0.468
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Structure of c3a-c3ar-go complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- C3a ligand (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of Apo-C3aR-Go complex (Titan)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8i9s
Q-score: 0.458
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (Complex from Homo sapiens)
- Structure of apo-c3ar-go complex (titan) (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of C5a bound human C5aR1 in complex with Go (Composite map)
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8ia2
Q-score: 0.441
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- C5a bound human c5ar1 in complex with go (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment - scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (28 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (Complex from Homo sapiens)
C3a-C3aR-Go (C3aR-Go complex only, Original Map)
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
C3a-C3aR-Go (C3a only, Original Map)
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]