PI 3-kinase alpha with nanobody 3-126
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8dcp
Q-score: 0.584
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Water (18 Da, Ligand)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-126 bound (Complex from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
PI 3-kinase alpha with nanobody 3-159
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8dcx
Q-score: 0.345
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-159 bound (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
PI 3-kinase alpha with nanobody 3-142
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8dd4
Q-score: 0.42
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Water (18 Da, Ligand)
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-142 bound (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
PI 3-kinase alpha with nanobody 3-142, crosslinked with DSG
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dd8
Q-score: 0.454
Hart JR, Liu X, Pan C, Liang A, Ueno L, Xu Y, Quezada A, Zou X, Yang S, Zhou Q, Schoonooghe S, Hassanzadeh-Ghassabeh G, Xia T, Shui W, Yang D, Vogt PK, Wang MW
PNAS (2022) 119 pp. e2210769119-e2210769119 [ DOI: doi:10.1073/pnas.2210769119 Pubmed: 36095215 ]
- Human pi 3-kinase alpha complex composed of p110alpha and p85alpha with nanobody 3-142 bound (Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (127 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 7x8r
Q-score: 0.554
Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW
PNAS (2022) 119 pp. e2200155119-e2200155119 [ Pubmed: 35561211 DOI: doi:10.1073/pnas.2200155119 ]
- 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid (1 kDa, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with boc5 and g protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7x8s
Q-score: 0.482
Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW
PNAS (2022) 119 pp. e2200155119-e2200155119 [ Pubmed: 35561211 DOI: doi:10.1073/pnas.2200155119 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid (1 kDa, Ligand)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with wb4-24 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7vqx
Q-score: 0.543
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ DOI: doi:10.1038/s41467-022-30041-z Pubmed: 35477937 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Vasoactive intestinal polypeptide receptor 2 (64 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) /g(s) /g(o) subunit gamma-2 (Complex from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex)
- Guanine nucleotide-binding protein g(i) /g(s) /g(t) subunit beta-1 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Bos taurus)
- Nanobody-35 (Complex)
- Human vasoactive intestinal polypeptide receptor 2 (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Pituitary adenylate cyclase activating peptide-27 (Complex from Bos taurus)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7wbj
Q-score: 0.425
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ DOI: doi:10.1038/s41467-022-30041-z Pubmed: 35477937 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from synthetic construct)
- Pituitary adenylate cyclase-activating polypeptide 27 (Complex from Bos taurus)
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Homo sapiens)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Vasoactive intestinal polypeptide receptor 2 (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short/g(i)/g(s)/g(o) subunit gamma-2 (Complex from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Vasoactive intestinal polypeptide receptor 2 (Complex)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Nanobody-35 (Complex)
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7vbh
Q-score: 0.397
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ DOI: doi:10.1038/s41467-022-28683-0 Pubmed: 35217653 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Peptide 20 (4 kDa, Protein from Homo sapiens)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with peptide 20 and g protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Cryo-em structure of the peptide 20-bound human glucagon-like peptide-1 receptor in complex with gs protein (Complex from Homo sapiens)
Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7fim
Q-score: 0.409
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ DOI: doi:10.1038/s41467-022-28683-0 Pubmed: 35217653 ]
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with tirzepatide and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor,glucagon-like peptide 1 receptor,glucagon-like peptide 1 receptor,glucagon-like peptide 1 receptor,human glucagon like peptide 1 receptor (68 kDa, Protein from Homo sapiens)
- Tirzepatide (4 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)