A neutralizing nanobody VHH60 against wt SARS-CoV-2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xki
Q-score: 0.441
Liu Q, Lu Y, Cai C, Huang Y, Zhou L, Guan Y, Fu S, Lin Y, Yan H, Zhang Z, Li X, Yang X, Yang H, Guo H, Lan K, Chen Y, Hou SC, Xiong Y
Cell Death Dis (2024) 15 pp. 458-458 [ Pubmed: 38937437 DOI: doi:10.1038/s41419-024-06802-7 ]
- Sars-cov-2 spike glycoprotein complex with vhh60 nanobody (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nanobody vhh60 (13 kDa, Protein from synthetic construct)
- Nanobody (Complex from synthetic construct)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Nb35 (15 kDa, Protein from Lama glama)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- Gs complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
Cryo-EM structure of Coxsackievirus B1 mature virion
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dpf
Q-score: 0.601
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Palmitic acid (256 Da, Ligand)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
Cryo-EM structure of Coxsackievirus B1 empty particle
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7dpg
Q-score: 0.542
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
Cryo-EM structure of Coxsackievirus B1 virion in complex with CAR
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dpz
Q-score: 0.511
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus and adenovirus receptor (13 kDa, Protein from Homo sapiens)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
Cryo-EM structure of Coxsackievirus B1 virion in complex with CAR at physiological temperature
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7dq1
Q-score: 0.512
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus and adenovirus receptor (13 kDa, Protein from Homo sapiens)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
Cryo-EM structure of CAR triggered Coxsackievirus B1 A-particle
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dq4
Q-score: 0.502
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 (Virus from Coxsackievirus B1)
Cryo-EM structure of Coxsackievirus B1 mature virion in complex with nAb 5F5
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7dq7
Q-score: 0.565
Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N
Cell Host Microbe (2021) 29 pp. 448-462.e5 [ DOI: doi:10.1016/j.chom.2021.01.001 Pubmed: 33539764 ]
- Vp2 (29 kDa, Protein from Coxsackievirus B1)
- Palmitic acid (256 Da, Ligand)
- Coxsackievirus b1 (Complex from Coxsackievirus B1)
- Nab 5f5 (Complex from Mus musculus)
- Vp3 (26 kDa, Protein from Coxsackievirus B1)
- Virion protein 1 (31 kDa, Protein from Coxsackievirus B1)
- 5f5 vh (13 kDa, Protein from Mus musculus)
- Capsid protein vp4 (7 kDa, Protein from Coxsackievirus B1)
- Coxsackievirus b1 complex with nab 5f5 (Complex)
- 5f5 vl (11 kDa, Protein from Mus musculus)