Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Nb35 (15 kDa, Protein from Lama glama)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- Gs complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7t9a
Q-score: 0.456
Melzi E, Willis J, Ma K, Lin Y, Kratochvil S, Berndsen ZT, Nair U, Warner J, Steichen J, Pecetta S, Perez M, Kirsch K, Ward AB, Schief W, Batista FD
Immunity (2022) [ ]
- Hiv-1 envelope apexgt2 in complex with pct64_lmca.hl_gt2_d42.16 fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv envelope apexgt2 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Gt2-d42.16 fab heavy chain (15 kDa, Protein from Mus musculus)
- Gt2-d42.16 fab light chain (11 kDa, Protein from Mus musculus)
- Hiv envelope apexgt2 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7t9b
Q-score: 0.438
Melzi E, Willis J, Ma K, Lin Y, Kratochvil S, Berndsen ZT, Nair U, Warner J, Steichen J, Pecetta S, Perez M, Kirsch K, Ward AB, Schief W, Batista FD
Immunity (2022) [ ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gt5-d42.16 fab light chain (11 kDa, Protein from Mus musculus)
- Gt5-d42.16 fab heavy chain (15 kDa, Protein from Mus musculus)
- Hiv-1 envelope apexgt5 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt5 in complex with gt5-d42.16 and rm20a3 fabs (Complex from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt5 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
Cryo-EM structure of cyanobacterial photosystem I in the presence of ferredoxin and cytochrome c6
Resolution: 1.97 Å
EM Method: Single-particle
Fitted PDBs: 7fix
Q-score: 0.651
Li J, Hamaoka N, Makino F, Kawamoto A, Lin Y, Rogner M, Nowaczyk MM, Lee YH, Namba K, Gerle C, Kurisu G
Commun Biol (2022) 5 pp. 951-951 [ Pubmed: 36097054 DOI: doi:10.1038/s42003-022-03926-4 ]
- Phylloquinone (450 Da, Ligand)
- Photosystem i p700 chlorophyll a apoprotein a2 (83 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Photosystem i reaction center subunit xii (3 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Ferredoxin-1 (10 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Beta-carotene (536 Da, Ligand)
- Photosystem i reaction center subunit viii (4 kDa, Protein from Thermosynechococcus vestitus BP-1)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- Cryo-em map of cyanobacterial photosystem i in the presence of ferredoxin and cytochrome c6 (1 MDa, Complex from Thermosynechococcus elongatus BP-1)
- Photosystem i reaction center subunit iv (8 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Water (18 Da, Ligand)
- Ga-substituted ferredoxin (Complex from Thermosynechococcus elongatus BP-1)
- Photosystem i trimer (Complex)
- Photosystem i reaction center subunit xi (16 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Chlorophyll a isomer (893 Da, Ligand)
- Photosystem i p700 chlorophyll a apoprotein a1 (83 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Photosystem i reaction center subunit ix (4 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Photosystem i reaction center subunit ii (15 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Calcium ion (40 Da, Ligand)
- Photosystem i iron-sulfur center (8 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Photosystem i reaction center subunit iii (19 kDa, Protein from Thermosynechococcus vestitus BP-1)
- Photosystem i reaction center subunit psak (8 kDa, Protein from Thermosynechococcus vestitus BP-1)
- [2ga-2s] cluster (203 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Chlorophyll a (893 Da, Ligand)
- Unknown ligand (40 Da, Ligand)
- Photosystem i 4.8k protein (4 kDa, Protein from Thermosynechococcus vestitus BP-1)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7wm0
Q-score: 0.295
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ DOI: doi:10.1016/j.chom.2022.03.035 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (state2) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Heavy chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down- and 2 up RBDs)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7wly
Q-score: 0.36
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ Pubmed: 35436443 DOI: doi:10.1016/j.chom.2022.03.035 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down-, 1 up- and 1 invisible RBDs)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7wlz
Q-score: 0.395
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ Pubmed: 35436443 DOI: doi:10.1016/j.chom.2022.03.035 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Heavy chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7e9n
Q-score: 0.31
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L
Signal Transduct Target Ther (2022) 7 pp. 114- [ DOI: doi:10.1038/s41392-022-00954-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Light chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Complex of the sars-cov-2 s-6p with 35b5 fab(1 down rbd, state1) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 7enf
Q-score: 0.485
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L
Signal Transduct Target Ther (2022) 7 pp. 114- [ DOI: doi:10.1038/s41392-022-00954-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- Light chain of fab30 (24 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 spike glycoprotein and fab30 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of fab30 (24 kDa, Protein from Homo sapiens)
- Fab30 (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)