Senktide bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jbf
Q-score: 0.524
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Scfv16 nanobody (32 kDa, Protein from Mus musculoides)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Senktide bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Neuromedin-k receptor (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq subunit alpha (41 kDa, Protein from Homo sapiens)
- Senktide (915 Da, Protein from Homo sapiens)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8hmp
Q-score: 0.514
Fan Y, Lin X, Pan B, Chen B, Liu D, Wuthrich K, Xu F
MedComm (2020) (2023) 4 pp. e260-e260 [ DOI: doi:10.1002/mco2.260 Pubmed: 37051308 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide (489 Da, Ligand)
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Gpr52 and gs with c17 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 52 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AsCas12f1-sgRNAv1-dsDNA ternary complex
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7wju
Q-score: 0.609
Wu Z, Liu D, Pan D, Shen H, Ji Q
To Be Published
- Ascas12f1-sgrnav1-dsdna ternary complex (Complex from Acidibacillus sulfuroxidans)
- Sgrnav1 (61 kDa, RNA from synthetic construct)
- Orfb_zn_ribbon domain-containing protein (48 kDa, Protein from Acidibacillus sulfuroxidans)
- Ascas12f1 (Complex from synthetic construct)
- Target strand (9 kDa, DNA from synthetic construct)
- Sgrna1 (Complex from synthetic construct)
- Dsdna (Complex)
- Non-target strand (1 kDa, DNA from synthetic construct)
Human TOM complex without cross-linking
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 7vd2
Q-score: 0.538
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF
PNAS (2022) 119 pp. e2200158119-e2200158119 [ DOI: doi:10.1073/pnas.2200158119 Pubmed: 35733257 ]
- Undecane (156 Da, Ligand)
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Human tom complex without cross-linking (Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
Human TOM complex with cross-linking
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 7vdd
Q-score: 0.332
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF
PNAS (2022) 119 pp. e2200158119-e2200158119 [ DOI: doi:10.1073/pnas.2200158119 Pubmed: 35733257 ]
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
- Human tom complex with cross-linking (Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7r6l
Q-score: 0.529
Liu D, Thelot FA, Piccirilli JA, Liao M, Yin P
Nat Methods (2022) 19 pp. 576-585 [ Pubmed: 35501384 DOI: doi:10.1038/s41592-022-01455-w ]
- Group i intron, 3 prime fragment plus 3 prime exon (11 kDa, Macromolecule from Tetrahymena thermophila)
- Group i intron, 5 prime fragment (121 kDa, RNA from Tetrahymena thermophila)
- Magnesium ion (24 Da, Ligand)
- 5 prime exon-free pre-2s intermediate of tetrahymena group i intron, symmetry-expanded monomer from a synthetic dimeric construct (130 kDa, Complex from Tetrahymena thermophila)
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 7r6m
Q-score: 0.389
Liu D, Thelot FA, Piccirilli JA, Liao M, Yin P
Nat Methods (2022) 19 pp. 576-585 [ Pubmed: 35501384 DOI: doi:10.1038/s41592-022-01455-w ]
- Post-2s intermediate of tetrahymena group i intron, symmetry-expanded monomer from a synthetic dimeric construct (130 kDa, Complex from Tetrahymena thermophila)
- Magnesium ion (24 Da, Ligand)
- Group i intron (128 kDa, RNA from Tetrahymena thermophila)
- Ligated exon mimic of the group i intron (4 kDa, Macromolecule from Tetrahymena thermophila)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7r6n
Q-score: 0.396
Liu D, Thelot FA, Piccirilli JA, Liao M, Yin P
Nat Methods (2022) 19 pp. 576-585 [ Pubmed: 35501384 DOI: doi:10.1038/s41592-022-01455-w ]
Structure of the human Meckelin
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7fh1
Q-score: 0.495
Sci Adv (2021) 7 pp. eabj9748-eabj9748 [ DOI: doi:10.1126/sciadv.abj9748 Pubmed: 34731008 ]
- Homodimer of meckelin (Complex from Homo sapiens)
- Meckelin (114 kDa, Protein from Homo sapiens)
Cryo_EM structure of delta N-NPC1L1-CLR
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7dfw
Q-score: 0.584
Hu M, Yang F, Huang Y, You X, Liu D, Sun S, Sui SF
Sci Adv (2021) 7 [ DOI: doi:10.1126/sciadv.abg3188 Pubmed: 34272236 ]
- Cholesterol (386 Da, Ligand)
- Npc1-like intracellular cholesterol transporter 1 (141 kDa, Protein from Homo sapiens)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Complex of delta n-npc1l1 with clr (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)