3-Methylcrotonyl-CoA Carboxylase in MCCD state with Acetyl CoA
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state with MCoA
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8jxm
Q-score: 0.289
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jxn
Q-score: 0.382
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Human TOM complex with cross-linking
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 7vdd
Q-score: 0.332
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF
PNAS (2022) 119 pp. e2200158119-e2200158119 [ Pubmed: 35733257 DOI: doi:10.1073/pnas.2200158119 ]
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Human tom complex with cross-linking (Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
Cryo_EM structure of delta N-NPC1L1-EZE
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7dfz
Q-score: 0.481
Hu M, Yang F, Huang Y, You X, Liu D, Sun S, Sui SF
Sci Adv (2021) 7 [ Pubmed: 34272236 DOI: doi:10.1126/sciadv.abg3188 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3~{r},4~{s})-1-(4-fluorophenyl)-3-[(3~{s})-3-(4-fluorophenyl)-3-oxidanyl-propyl]-4-(4-hydroxyphenyl)azetidin-2-one (409 Da, Ligand)
- Delta n-hnpc1l1-eze (Complex from Homo sapiens)
- Npc1-like intracellular cholesterol transporter 1 (139 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7df8
Q-score: 0.54
Hu M, Yang F, Huang Y, You X, Liu D, Sun S, Sui SF
Sci Adv (2021) 7 [ Pubmed: 34272236 DOI: doi:10.1126/sciadv.abg3188 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Full length npc1l1 (Cell from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Npc1-like intracellular cholesterol transporter 1 (139 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 6jlu
Q-score: 0.385
Pi X, Zhao S, Wang W, Liu D, Xu C, Han G, Kuang T, Sui SF, Shen JR
Science (2019) 365 [ Pubmed: 31371578 DOI: doi:10.1126/science.aax4406 ]
- Extrinsic protein in photosystem ii (10 kDa, Protein from Chaetoceros gracilis)
- Psbg (6 kDa, Protein from Chaetoceros gracilis)
- Psbj (3 kDa, Protein from Chaetoceros gracilis)
- Psii-fcp supercomplex (Complex from Chaetoceros gracilis)
- Psbk (4 kDa, Protein from Chaetoceros gracilis)
- 2,3-dimethyl-5-(3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaenyl-2,5-cyclohexadiene-1,4-dione-2,3-dimethyl-5-solanesyl-1,4-benzoquinone (749 Da, Ligand)
- Psb34 (2 kDa, Protein from Chaetoceros gracilis)
- Beta-carotene (536 Da, Ligand)
- Chlorophyll c1 (610 Da, Ligand)
- Psbw (5 kDa, Protein from Chaetoceros gracilis)
- Photosystem ii reaction center protein h (7 kDa, Protein from Chaetoceros gracilis)
- Bicarbonate ion (61 Da, Ligand)
- Psbm (4 kDa, Protein from Chaetoceros gracilis)
- Fe (ii) ion (55 Da, Ligand)
- Psbe (9 kDa, Protein from Chaetoceros gracilis)
- Psbt (3 kDa, Protein from Chaetoceros gracilis)
- 1,2-dipalmitoyl-phosphatidyl-glycerole (722 Da, Ligand)
- (3s,3's,5r,5'r,6s,6'r,8'r)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'-yl acetate (658 Da, Ligand)
- Chlorophyll c2 (608 Da, Ligand)
- Water (18 Da, Ligand)
- Cytochrome c-550 (14 kDa, Protein from Chaetoceros gracilis)
- Chloride ion (35 Da, Ligand)
- Extrinsic protein in photosystem ii (26 kDa, Protein from Chaetoceros gracilis)
- 1,2-di-o-acyl-3-o-[6-deoxy-6-sulfo-alpha-d-glucopyranosyl]-sn-glycerol (795 Da, Ligand)
- (3s,3'r,5r,6s,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol (582 Da, Ligand)
- Pheophytin a (871 Da, Ligand)
- Psbl (4 kDa, Protein from Chaetoceros gracilis)
- 1,2-distearoyl-monogalactosyl-diglyceride (787 Da, Ligand)
- Extrinsic protein in photosystem ii (22 kDa, Protein from Chaetoceros gracilis)
- Psbf (3 kDa, Protein from Chaetoceros gracilis)
- Psbi (3 kDa, Protein from Chaetoceros gracilis)
- Fcp-a (18 kDa, Protein from Chaetoceros gracilis)
- Psbb (56 kDa, Protein from Chaetoceros gracilis)
- Fcp-e (18 kDa, Protein from Chaetoceros gracilis)
- Psb31 (18 kDa, Protein from Chaetoceros gracilis)
- Psby (3 kDa, Protein from Chaetoceros gracilis)
- Photosystem ii reaction center x protein (3 kDa, Protein from Chaetoceros gracilis)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Psba (39 kDa, Protein from Chaetoceros gracilis)
- Psbd (37 kDa, Protein from Chaetoceros gracilis)
- Psbc (49 kDa, Protein from Chaetoceros gracilis)
- Ca-mn4-o5 cluster (339 Da, Ligand)
- Chlorophyll a (893 Da, Ligand)
- Digalactosyl diacyl glycerol (dgdg) (949 Da, Ligand)
- Fcp-f (18 kDa, Protein from Chaetoceros gracilis)
- Psbz (6 kDa, Protein from Chaetoceros gracilis)
- Fcp-d (24 kDa, Protein from Chaetoceros gracilis)
Local map for the core region of the phycobilisome from the red alga Griffithsia pacifica