Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8jaw
Q-score: 0.506
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Dodecamer of human mcc (Complex from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8j7d
Q-score: 0.435
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Human mcc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8j4z
Q-score: 0.418
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2025) 32 pp. 73-85 [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Heterododecamer of human mcc (Complex from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-4-[[[(2~{s},3~{s},4~{s},5~{s})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate (849 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Neurokinin B bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jbg
Q-score: 0.569
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Neuromedin-k receptor (nk3r-pfastbac1) (158 kDa, Protein from Homo sapiens)
- Neurokinin b bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Neurokinin-b (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein gq (g324) (41 kDa, Protein from Homo sapiens)
- Scfv16 nanobody (32 kDa, Protein from Mus musculus)
Substance P bound to active human neurokinin 3 receptor in complex with Gq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jbh
Q-score: 0.575
Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C
Cell Discov (2023) 9 pp. 66-66 [ Pubmed: 37391393 DOI: doi:10.1038/s41421-023-00564-w ]
- Substance p bound to active human neurokinin 3 receptor in complex with gq heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 nanobody (32 kDa, Protein from Mus musculoides)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Nk3r-pfastbac1 (158 kDa, Protein from Homo sapiens)
- Peptide from protachykinin-1 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq subunit alpha (g324) (41 kDa, Protein from Homo sapiens)
Human propionyl-coenzyme A carboxylase
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7ybu
Q-score: 0.54
Su J, Tian X, Cheng H, Liu D, Wang Z, Sun S, Wang HW, Sui SF
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01379-3 Pubmed: 39223421 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Human propionyl-coenzyme a carboxylase heterododecomer (Complex from Homo sapiens)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
- 5-(hexahydro-2-oxo-1h-thieno[3,4-d]imidazol-6-yl)pentanal (228 Da, Ligand)
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8hmp
Q-score: 0.514
Fan Y, Lin X, Pan B, Chen B, Liu D, Wuthrich K, Xu F
MedComm (2020) (2023) 4 pp. e260-e260 [ DOI: doi:10.1002/mco2.260 Pubmed: 37051308 ]
- Gpr52 and gs with c17 (Complex from Homo sapiens)
- N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide (489 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 52 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the AsCas12f1-sgRNAv1-dsDNA ternary complex
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7wju
Q-score: 0.609
Wu Z, Liu D, Pan D, Shen H, Ji Q
To Be Published
- Ascas12f1 (Complex from synthetic construct)
- Dsdna (Complex)
- Ascas12f1-sgrnav1-dsdna ternary complex (Complex from Acidibacillus sulfuroxidans)
- Orfb_zn_ribbon domain-containing protein (48 kDa, Protein from Acidibacillus sulfuroxidans)
- Non-target strand (1 kDa, DNA from synthetic construct)
- Sgrna1 (Complex from synthetic construct)
- Target strand (9 kDa, DNA from synthetic construct)
- Sgrnav1 (61 kDa, RNA from synthetic construct)
Human TOM complex without cross-linking
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 7vd2
Q-score: 0.538
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF
PNAS (2022) 119 pp. e2200158119-e2200158119 [ Pubmed: 35733257 DOI: doi:10.1073/pnas.2200158119 ]
- Human tom complex without cross-linking (Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom5 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom22 homolog (15 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Undecane (156 Da, Ligand)
- Mitochondrial import receptor subunit tom40 homolog (37 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom7 homolog (6 kDa, Protein from Homo sapiens)
- Mitochondrial import receptor subunit tom6 homolog (8 kDa, Protein from Homo sapiens)
Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7w9k
Q-score: 0.507
Huang G, Liu D, Wang W, Wu Q, Chen J, Pan X, Shen H, Yan N
Cell Rep (2022) 39 pp. 110735-110735 [ Pubmed: 35476982 DOI: doi:10.1016/j.celrep.2022.110735 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits (279 MDa, Complex from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Sodium channel subunit beta-1 (24 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)