Cryo-EM structure of human proteasome assembly intermediate half-proteasome
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8yix
Q-score: 0.589
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) 11 pp. eadr7943-eadr7943 [ DOI: doi:10.1126/sciadv.adr7943 Pubmed: 39792683 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Cryo-em structure of human proteasome assembly intermediate half-proteasome (Complex from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of human proteasome assembly intermediate preholo-1
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8yiy
Q-score: 0.431
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) 11 pp. eadr7943-eadr7943 [ DOI: doi:10.1126/sciadv.adr7943 Pubmed: 39792683 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Cryo-em structure of human proteasome assembly intermediate preholo-1 (Complex from Homo sapiens)
- Proteasome subunit beta type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of human proteasome assembly intermediate preholo-2
Resolution: 3.79 Å
EM Method: Single-particle
Fitted PDBs: 8yiz
Q-score: 0.393
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) 11 pp. eadr7943-eadr7943 [ DOI: doi:10.1126/sciadv.adr7943 Pubmed: 39792683 ]
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Cryo-em structure of human proteasome assembly intermediate preholo-2 (Complex from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of native H2AK119bu nucleosome at 2.6
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8vlr
Q-score: 0.602
Shen XY, Chen CX, Wang Y, Zheng W, Zheng JH, Jones AE, Zhu B, Zhang H, Lyons C, Rijal A, Moley JA, Cao GS, Liu K, Winn R, McGinty RK, Zhang K, Wang HB
To Be Published
- Histone h4 (9 kDa, Protein from Homo sapiens)
- Histone h2b type 1-a (10 kDa, Protein from Homo sapiens)
- Histone h2a type 1-b/e (11 kDa, Protein from Homo sapiens)
- Histone h3.1 (11 kDa, Protein from Homo sapiens)
- Dna (136-mer) (41 kDa, DNA from Homo sapiens)
- Dna (136-mer) (42 kDa, DNA from Homo sapiens)
- Native h2ak119bu nucleosome (Complex from Homo sapiens)
mouse TMEM63b in LMNG-CHS micelle
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8wg3
Q-score: 0.456
Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K
To Be Published
- Mouse tmem63b (100 kDa, Complex from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Csc1-like protein 2,green fluorescent protein (126 kDa, Protein from Aequorea victoria)
- Cholesterol hemisuccinate (486 Da, Ligand)
mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wg4
Q-score: 0.478
Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K
To Be Published
- Mouse tmem63b (100 kDa, Complex from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Csc1-like protein 2,green fluorescent protein (126 kDa, Protein from Aequorea victoria)
- Cholesterol hemisuccinate (486 Da, Ligand)
EB-bound E46K alpha-synuclein fibrils
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
PNAS (2024) 121 pp. e2321633121-e2321633121 [ Pubmed: 39172784 DOI: doi:10.1073/pnas.2321633121 ]
- Eb-bound e46k alpha-synuclein fibril (Complex from Homo sapiens)
- 4-azanyl-6-[[4-[4-[(~{e})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid (872 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
CR-bound E46K alpha-synuclein fibrils
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8x7m
Q-score: 0.115
PiB-bound E46K mutanted alpha-synuclein fibrils
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 8x7o
Q-score: 0.464
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
PNAS (2024) 121 pp. e2321633121-e2321633121 [ Pubmed: 39172784 DOI: doi:10.1073/pnas.2321633121 ]
- Pib-bound e46k mutated alpha-synuclein fibril (Complex from Homo sapiens)
- 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol (256 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)