mouse TMEM63b in LMNG-CHS micelle
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8wg3
Q-score: 0.456
Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K
To Be Published
- Mouse tmem63b (100 kDa, Complex from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Csc1-like protein 2,green fluorescent protein (126 kDa, Protein from Aequorea victoria)
- Cholesterol hemisuccinate (486 Da, Ligand)
mouse TMEM63b in DDM-CHS micelle with YN9303-24 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wg4
Q-score: 0.478
Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K
To Be Published
- Mouse tmem63b (100 kDa, Complex from Mus musculus)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Csc1-like protein 2,green fluorescent protein (126 kDa, Protein from Aequorea victoria)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with white-tailed deer ACE2
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8hfx
Q-score: 0.46
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ Pubmed: 37676003 DOI: doi:10.1128/jvi.00505-23 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron ba.1 spike protein, envelope glycoprotein chimera in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme (71 kDa, Protein from Odocoileus virginianus texanus)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein,envelope glycoprotein (139 kDa, Protein from Human immunodeficiency virus 1)
cryo-EM structure of omicron spike in complex with de novo designed binder, full map
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7zrv
Q-score: 0.4
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ DOI: doi:10.1038/s41586-023-05993-x Pubmed: 37100904 ]
- Spike glycoprotein,envelope glycoprotein (142 kDa, Protein from Tequatrovirus T4)
- De novo designed binder (Complex from Drosophila melanogaster)
- Omicron spike in complex with de novo designed binder, full map (Complex)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
cryo-EM structure of omicron spike in complex with de novo designed binder, local
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 7zsd
Q-score: 0.431
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ Pubmed: 37100904 DOI: doi:10.1038/s41586-023-05993-x ]
- De novo designed binder (Complex from Drosophila melanogaster)
- Omicron spike in complex with de novo designed binder (450 kDa, Complex)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- Omicron spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 7zss
Q-score: 0.453
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE
Nature (2023) 617 pp. 176-184 [ Pubmed: 37100904 DOI: doi:10.1038/s41586-023-05993-x ]
- D614g spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- De novo designed binder (Complex from Drosophila melanogaster)
- De novo designed binder (8 kDa, Protein from Drosophila melanogaster)
- D614g spike in complex with de novo designed binder (450 kDa, Complex)
- Spike glycoprotein (126 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with mouse ACE2
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 7wrh
Q-score: 0.468
Li L, Han P, Huang B, Xie Y, Li W, Zhang D, Han P, Xu Z, Bai B, Zhou J, Kang X, Li X, Zheng A, Zhang R, Qiao S, Zhao X, Qi J, Wang Q, Liu K, Gao GF
Cell Discov (2022) 8 pp. 65-65 [ Pubmed: 35821014 DOI: doi:10.1038/s41421-022-00431-0 ]
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 omicron ba.1 spike protein with mouse ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mouse ace2 (Complex)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.1 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of a class A GPCR
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6lfm
Q-score: 0.461
Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ
Nature (2020) 585 pp. 135-140 [ Pubmed: 32610344 DOI: doi:10.1038/s41586-020-2492-5 ]
- Cholesterol (386 Da, Ligand)
- Interleukin-8 (8 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Ternary complex of chemokine, gpcr and g protein (150 kDa, Complex from Homo sapiens)
- C-x-c chemokine receptor type 2 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of a class A GPCR monomer
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6lfo
Q-score: 0.441
Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ
Nature (2020) 585 pp. 135-140 [ DOI: doi:10.1038/s41586-020-2492-5 Pubmed: 32610344 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Interleukin-8 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- C-x-c chemokine receptor type 2 (40 kDa, Protein from Homo sapiens)
- Ternary complex of chemokine-monomer, gpcr and g protein (150 kDa, Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- A12v163-b.01 heavy chain (Protein from Macaca mulatta)
- Pgt122 heavy chain (Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip gp41 (Protein from Human immunodeficiency virus 1)
- Quaternary complex of hiv-1 env bg505 ds-sosip with antibodies a12v163-b.01, vrc03 and pgt122. (630 kDa, Complex)
- Pgt122 (Complex from Homo sapiens)
- A12v163-b.01 light chain (Protein from Macaca mulatta)
- Hiv-1 env bg505 ds-sosip gp41 (Complex from Human immunodeficiency virus 1)
- Hiv-1 env bg505 ds-sosip gp120 (Protein from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- A12v163-b.01 (Complex from Macaca mulatta)
- Pgt122 light chain (Protein from Homo sapiens)
- Vrc03 light chain (Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 heavy chain (Protein from Homo sapiens)