Cryo-EM structure of PCSK9 mimic HIT01-K21Q-R218E with AMG145 Fab
Zhang B, Chuang GY, Biju A, Biner D, Cheng J, Wang Y, Bao S, Chao CW, Lei H, Liu T, Nazzari AF, Yang Y, Zhou T, Chen SJ, Chen X, Kong WP, Ou L, Parchment DK, Sarfo EK, SiMa H, Todd JP, Wang S, Woodward RA, Cheng C, Rawi R, Mascola JR, Kwong PD
Cell Rep (2024) 43 pp. 114285-114285 [ DOI: doi:10.1016/j.celrep.2024.114285 Pubmed: 38819987 ]
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 8t5c
Q-score: 0.301
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ DOI: doi:10.1038/s41467-023-44534-y Pubmed: 38177144 ]
- Glycoprotein g1 (22 kDa, Protein from Lassa virus Josiah)
- D5 nanobody (13 kDa, Protein from Camelus bactrianus)
- Glycoprotein g2 (22 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa gpc trimer in complex with fab 8.11g and nanobody d5 (Complex from Lassa virus Josiah)
- 8.11g light chain (12 kDa, Protein from Homo sapiens)
- 8.11g heavy chain (13 kDa, Protein from Homo sapiens)
Lassa GPC trimer in complex with Fab GP23
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ DOI: doi:10.1038/s41467-023-44534-y Pubmed: 38177144 ]
Ligand-free Lassa GPC Trimer with C3 Symmetry
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ DOI: doi:10.1038/s41467-023-44534-y Pubmed: 38177144 ]
- Lassa gpc (Protein from Lassa virus Josiah)
- Lassa gpc trimer (Complex from Lassa virus Josiah)
Ligand-free Lassa GPC Trimer with C1 Symmetry
Gorman J, Cheung CS, Duan Z, Ou L, Wang M, Chen X, Cheng C, Biju A, Sun Y, Wang P, Yang Y, Zhang B, Boyington JC, Bylund T, Charaf S, Chen SJ, Du H, Henry AR, Liu T, Sarfo EK, Schramm CA, Shen CH, Stephens T, Teng IT, Todd JP, Tsybovsky Y, Verardi R, Wang D, Wang S, Wang Z, Zheng CY, Zhou T, Douek DC, Mascola JR, Ho DD, Ho M, Kwong PD
Nat Commun (2024) 15 pp. 285-285 [ DOI: doi:10.1038/s41467-023-44534-y Pubmed: 38177144 ]