Cryo-EM structure of opioid receptor with biased agonist
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8y45
Q-score: 0.407
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B
Nat Commun (2024) 15 pp. 8284-8284 [ Pubmed: 39333070 DOI: doi:10.1038/s41467-024-52601-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Delta-type opioid receptor (36 kDa, Protein from Homo sapiens)
- ~{n},~{n}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide (392 Da, Ligand)
- Cryo-em structure of opioid receptor with biased agonist (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Nb35 (15 kDa, Protein from Lama glama)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- Gs complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)