Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8hk2
Q-score: 0.48
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- C3ar-gi-c3a protein complex (160 kDa, Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- C3a anaphylatoxin (9 kDa, Protein from Homo sapiens)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hk3
Q-score: 0.438
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- C3a anaphylatoxin chemotactic receptor (53 kDa, Protein from Homo sapiens)
- C3ar-gi-apo protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hk5
Q-score: 0.456
Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y
Nat Chem Biol (2023) 19 pp. 1351-1360 [ DOI: doi:10.1038/s41589-023-01339-w Pubmed: 37169960 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (7 kDa, Protein from Bos taurus)
- C5a anaphylatoxin chemotactic receptor 1 (39 kDa, Protein from Homo sapiens)
- Complement c5 (8 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- C5ar1-gi-c5a protein complex (160 kDa, Complex from Homo sapiens)
Gi bound mu-opioid receptor in complex with beta-endorphin
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8f7q
Q-score: 0.455
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Beta-endorphin (3 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Gi bound mu-opioid receptor in complex with endomorphin
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8f7r
Q-score: 0.395
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Mu-type opioid receptor (45 kDa, Protein from Homo sapiens)
- Endomorphin (609 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Gi bound delta-opioid receptor in complex with deltorphin
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8f7s
Q-score: 0.498
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Deltorphin (781 Da, Protein from Phyllomedusa)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Delta-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Gi bound kappa-opioid receptor in complex with dynorphin
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8f7w
Q-score: 0.456
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Kappa-type opioid receptor (42 kDa, Protein from Homo sapiens)
- Dynorphin (983 Da, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Gi bound nociceptin receptor in complex with nociceptin peptide
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8f7x
Q-score: 0.45
Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE
Cell (2023) 186 pp. 413-427.e17 [ Pubmed: 36638794 DOI: doi:10.1016/j.cell.2022.12.026 ]
- Nociceptin receptor (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gi bound mu-opioid receptor in complex with beta-endorphin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Nociceptin (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
Fentanyl-bound mu-opioid receptor-Gi complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ef5
Q-score: 0.39
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- N-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (336 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Morphine-bound mu-opioid receptor-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ef6
Q-score: 0.471
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE
Cell (2022) 185 pp. 4361-4375.e19 [ DOI: doi:10.1016/j.cell.2022.09.041 Pubmed: 36368306 ]
- Fentanyl bound mu-opioid receptor-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Mu-type opioid receptor (41 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (7r,7as,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1h-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol (285 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)