CryoEM structure of BAM in complex with the PTB1 closed-state inhibitor (in DDM detergent)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 9cnx
Q-score: 0.461
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ Pubmed: 39379361 DOI: doi:10.1038/s41467-024-52512-1 ]
- Circular peptide (1 kDa, Protein from synthetic construct)
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
- Zinc ion (65 Da, Ligand)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
Structure of BAM complexed with PTB2 ligand in detergent
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cnz
Q-score: 0.482
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ Pubmed: 39379361 DOI: doi:10.1038/s41467-024-52512-1 ]
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Ptb2 circular peptide (2 kDa, Protein from synthetic construct)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
CryoEM structure of BAM in complex with the PTB2 open-state inhibitor (in SMA nanodisc)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9co0
Q-score: 0.466
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ Pubmed: 39379361 DOI: doi:10.1038/s41467-024-52512-1 ]
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Ptb2 circular peptide (2 kDa, Protein from synthetic construct)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
Cryo-EM structure of RDGC/apo-CaM complex
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8jfw
Q-score: 0.431
To Be Published
- Fe (iii) ion (55 Da, Ligand)
- Cryo-em structure of rdgc/apo-cam complex (Complex from Drosophila melanogaster)
- At15141p (16 kDa, Protein from Drosophila melanogaster)
- Serine/threonine-protein phosphatase rdgc (75 kDa, Protein from Drosophila melanogaster)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of opioid receptor with biased agonist
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8y45
Q-score: 0.407
Cheng L, Miao Z, Liu S, Li Z, Fu H, Xu C, Hu S, Zhao C, Liu Y, Zhao T, Liu W, Wang H, Liu R, Yan W, Tang X, Liu J, Shao Z, Ke B
Nat Commun (2024) 15 pp. 8284-8284 [ Pubmed: 39333070 DOI: doi:10.1038/s41467-024-52601-1 ]
- Cryo-em structure of opioid receptor with biased agonist (Complex from Homo sapiens)
- Delta-type opioid receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- ~{n},~{n}-diethyl-4-(5-oxidanylspiro[chromene-2,4'-piperidine]-4-yl)benzamide (392 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
Extracellular domain of GC-A bound to ANP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcq
Q-score: 0.599
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01426-z Pubmed: 39543315 ]
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Cyclase domain of GC-A bound to ANP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9bcv
Q-score: 0.564
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 (115 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fab fragment (10 kDa, Protein from Mus musculus)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- G-protein complex (93 kDa, Complex from Homo sapiens)
Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wos
Q-score: 0.418
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8wot
Q-score: 0.458
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)