CryoEM structure of BAM in complex with the PTB1 closed-state inhibitor (in DDM detergent)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 9cnx
Q-score: 0.461
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ DOI: doi:10.1038/s41467-024-52512-1 Pubmed: 39379361 ]
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
- Circular peptide (1 kDa, Protein from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
Structure of BAM complexed with PTB2 ligand in detergent
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cnz
Q-score: 0.482
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ DOI: doi:10.1038/s41467-024-52512-1 Pubmed: 39379361 ]
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
- Ptb2 circular peptide (2 kDa, Protein from synthetic construct)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
CryoEM structure of BAM in complex with the PTB2 open-state inhibitor (in SMA nanodisc)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9co0
Q-score: 0.466
Sun D, Storek KM, Tegunov D, Yang Y, Arthur CP, Johnson M, Quinn JG, Liu W, Han G, Girgis HS, Alexander MK, Murchison AK, Shriver S, Tam C, Ijiri H, Inaba H, Sano T, Yanagida H, Nishikawa J, Heise CE, Fairbrother WJ, Tan MW, Skelton N, Sandoval W, Sellers BD, Ciferri C, Smith PA, Reid PC, Cunningham CN, Rutherford ST, Payandeh J
Nat Commun (2024) 15 pp. 8718-8718 [ DOI: doi:10.1038/s41467-024-52512-1 Pubmed: 39379361 ]
- Outer membrane protein assembly factor bamc (36 kDa, Protein from Escherichia coli)
- Ptb2 circular peptide (2 kDa, Protein from synthetic construct)
- Outer membrane protein assembly factor bama (90 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bamd (27 kDa, Protein from Escherichia coli)
- Outer membrane protein assembly factor bame (13 kDa, Protein from Escherichia coli)
- Bamabcde complex (Complex from Escherichia coli)
- Outer membrane protein assembly factor bamb (41 kDa, Protein from Escherichia coli)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- G-protein complex (93 kDa, Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wos
Q-score: 0.418
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8wot
Q-score: 0.458
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ DOI: doi:10.1038/s41421-024-00647-2 Pubmed: 38378654 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8iaj
Q-score: 0.567
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM, Gong X
Cell Rep (2024) 43 pp. 113717-113717 [ Pubmed: 38285738 DOI: doi:10.1016/j.celrep.2024.113717 ]
- Serine palmitoyltransferase-regulating protein tsc3 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Protein orm2 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
- N-[(2s,3r,4e)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide (650 Da, Ligand)
- Spt-orm2 complex (Complex from Saccharomyces cerevisiae)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Saccharomyces cerevisiae)
- Chimera of long chain base biosynthesis protein 1 and serine palmitoyltransferase 1 (59 kDa, Protein from Saccharomyces cerevisiae S288C )
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A-N71A) complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8iak
Q-score: 0.548
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM, Gong X
Cell Rep (2024) 43 pp. 113717-113717 [ Pubmed: 38285738 DOI: doi:10.1016/j.celrep.2024.113717 ]
- Protein orm2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Serine palmitoyltransferase-regulating protein tsc3 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Chimera of long chain base biosynthesis protein 1 and serine palmitoyltransferase 1 (59 kDa, Protein from Saccharomyces cerevisiae S288C)
- Spt-orm2 complex (Complex from Saccharomyces cerevisiae)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8iam
Q-score: 0.556
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM, Gong X
Cell Rep (2024) 43 pp. 113717-113717 [ Pubmed: 38285738 DOI: doi:10.1016/j.celrep.2024.113717 ]
- Chimera of long chain base biosynthesis protein 1 and serine palmitoyltransferase 1 (59 kDa, Protein from Saccharomyces cerevisiae)
- Serine palmitoyltransferase-regulating protein tsc3 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- N-[(2s,3r,4e)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide (650 Da, Ligand)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Saccharomyces cerevisiae)
- Spt-orm2 complex (Complex from Saccharomyces cerevisiae)
- Protein orm2 (24 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM Structure of NINJ2 Filament at 3.07 Angstrom Resolution
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8szb
Q-score: 0.424
Sahoo B, Mou Z, Liu W, Dubyak G, Dai X
Cell (2025) 188 pp. 292-302.e11 [ Pubmed: 39667936 DOI: doi:10.1016/j.cell.2024.11.021 ]
- Cholesterol (386 Da, Ligand)
- Ninjurin-2 in complex with cholesterol (Cellular component from Homo sapiens)
- Ninjurin-2 (18 kDa, Protein from Homo sapiens)