Extracellular domain of apo GC-A, state 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcl
Q-score: 0.59
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Extracellular domain of apo GC-A, state 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bcn
Q-score: 0.595
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Intracellular domain of apo GC-A
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bco
Q-score: 0.344
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Kinase homology domain of apo GC-A
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcp
Q-score: 0.398
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
Extracellular domain of GC-A bound to ANP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcq
Q-score: 0.599
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Intracellular domain of GC-A bound to ANP
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 9bcs
Q-score: 0.359
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (116 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cyclase domain of GC-A bound to ANP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9bcv
Q-score: 0.564
Liu S, Payne AM, Wang J, Zhu L, Paknejad N, Eng ET, Liu W, Miao Y, Hite RK, Huang XY
Nat Struct Mol Biol (2024) [ Pubmed: 39543315 DOI: doi:10.1038/s41594-024-01426-z ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Atrial natriuretic peptide receptor 1 dimer (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Fab fragment (10 kDa, Protein from Mus musculus)
- Atrial natriuretic peptide receptor 1 (115 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR119-Gs-Nb35 complex with small molecule agonist MBX-2982
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8vhf
Q-score: 0.449
Kim D-G, Liu W, Viner R, Cherezov V
To Be Published
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,glucose-dependent insulinotropic receptor,lgbit (67 kDa, Protein from Oplophorus gracilirostris)
- Nanobody35 (15 kDa, Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, hibit (40 kDa, Protein from Homo sapiens)
- The complex of gpr119-gs-nb35 (composite map) (177 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- G-protein complex (93 kDa, Complex from Homo sapiens)
- Nanobody35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (67 kDa, Complex from Escherichia coli)
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8iaj
Q-score: 0.567
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM, Gong X
Cell Rep (2024) 43 pp. 113717-113717 [ Pubmed: 38285738 DOI: doi:10.1016/j.celrep.2024.113717 ]
- Serine palmitoyltransferase-regulating protein tsc3 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Protein orm2 (24 kDa, Protein from Saccharomyces cerevisiae S288C)
- N-[(2s,3r,4e)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide (650 Da, Ligand)
- Spt-orm2 complex (Complex from Saccharomyces cerevisiae)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Saccharomyces cerevisiae)
- Chimera of long chain base biosynthesis protein 1 and serine palmitoyltransferase 1 (59 kDa, Protein from Saccharomyces cerevisiae S288C )
Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A-N71A) complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8iak
Q-score: 0.548
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, Zhong J, Niranjanakumari S, Gable K, Gupta SD, Liu W, Harrison PJ, Campopiano DJ, Dunn TM, Gong X
Cell Rep (2024) 43 pp. 113717-113717 [ Pubmed: 38285738 DOI: doi:10.1016/j.celrep.2024.113717 ]
- Protein orm2 (24 kDa, Protein from Saccharomyces cerevisiae)
- Serine palmitoyltransferase-regulating protein tsc3 (9 kDa, Protein from Saccharomyces cerevisiae)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Chimera of long chain base biosynthesis protein 1 and serine palmitoyltransferase 1 (59 kDa, Protein from Saccharomyces cerevisiae S288C)
- Spt-orm2 complex (Complex from Saccharomyces cerevisiae)
- Serine palmitoyltransferase 2 (63 kDa, Protein from Saccharomyces cerevisiae)