Human NRAMP1 (SLC11A1) in complex with manganese, towards the inward-open state
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9f6p
Q-score: 0.351
Liziczai M, Fuchs A, Manatschal C, Dutzler R
Nat Commun (2025) 16 pp. 761-761 [ Pubmed: 39824808 DOI: doi:10.1038/s41467-024-54705-0 ]
- Natural resistance-associated macrophage protein 1 (67 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Complex of nramp1 with manganese (60 MDa, Complex from Homo sapiens)
Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with manganese, in an occluded state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9f6n
Q-score: 0.438
Liziczai M, Fuchs A, Manatschal C, Dutzler R
Nat Commun (2025) 16 pp. 761-761 [ Pubmed: 39824808 DOI: doi:10.1038/s41467-024-54705-0 ]
- Complex of dmt1 with manganese ion (65 MDa, Complex from Homo sapiens)
- Natural resistance-associated macrophage protein 2 (71 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
Human divalent metal transporter 1 (DMT1/SLC11A2) in complex with sybody 1, in an occluded state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9f6o
Q-score: 0.369
Liziczai M, Fuchs A, Manatschal C, Dutzler R
Nat Commun (2025) 16 pp. 761-761 [ Pubmed: 39824808 DOI: doi:10.1038/s41467-024-54705-0 ]
- Complex of dmt1 and sybody 1 (80 MDa, Complex from Homo sapiens)
- Sybody 1 (16 kDa, Protein from synthetic construct)
- Natural resistance-associated macrophage protein 2 (71 kDa, Protein from Homo sapiens)
Human NRAMP1 (SLC11A1) in an occluded state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 9f6q
Q-score: 0.279
Liziczai M, Fuchs A, Manatschal C, Dutzler R
Nat Commun (2025) 16 pp. 761-761 [ Pubmed: 39824808 DOI: doi:10.1038/s41467-024-54705-0 ]
- Nramp1 (60 MDa, Complex from Homo sapiens)
- Natural resistance-associated macrophage protein 1 (67 kDa, Protein from Homo sapiens)
Structure of Setaria italica NRAT in complex with a nanobody
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 8ont
Q-score: 0.467
Ramanadane K, Liziczai M, Markovic D, Straub MS, Rosalen GT, Udovcic A, Dutzler R, Manatschal C
eLife (2023) 12 [ DOI: doi:10.7554/eLife.85641 Pubmed: 37074929 ]
- Water (18 Da, Ligand)
- Nanobody1 (13 kDa, Protein from Lama glama)
- Nramp related aluminium transporter (60 kDa, Protein from Setaria italica)
- Complex between sinrat and a nanobody used as a fiducial marker for structure determination (Complex from Setaria italica)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bzy
Q-score: 0.522
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ DOI: doi:10.7554/eLife.83053 Pubmed: 36943194 ]
- 2-[2-[2-(1~{h}-benzimidazol-2-yl)ethylamino]ethyl]-~{n}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide (408 Da, Ligand)
- Sybody 3 (16 kDa, Protein from synthetic construct)
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- Complex of ferroportin with synthetic nanobody and inhibitor (Complex from Homo sapiens)
- Diundecyl phosphatidyl choline (622 Da, Ligand)
Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation
Resolution: 4.09 Å
EM Method: Single-particle
Fitted PDBs: 8c02
Q-score: 0.349
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ DOI: doi:10.7554/eLife.83053 Pubmed: 36943194 ]
- Solute carrier family 40 member 1 (63 kDa, Protein from Homo sapiens)
- Complex of ferroportin with synthetic nanobody (Complex from Homo sapiens)
- Sybody3 (16 kDa, Protein from synthetic construct)
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8c03
Q-score: 0.399
Lehmann EF, Liziczai M, Drozdzyk K, Altermatt P, Langini C, Manolova V, Sundstrom H, Durrenberger F, Dutzler R, Manatschal C
eLife (2023) 12 [ DOI: doi:10.7554/eLife.83053 Pubmed: 36943194 ]