Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7niu
Q-score: 0.333
Nosol K, Bang-Sorensen R, Irobalieva RN, Erramilli SK, Stieger B, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34385322 DOI: doi:10.1073/pnas.2106702118 ]
- Phosphatidylcholine translocator abcb4 (Complex from Homo sapiens)
- 4b1 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Qa2 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- 4b1 fab-fragment heavy chain (25 kDa, Protein from Homo sapiens)
- Nanodisc reconstituted human abcb4 in complex with 4b1-fab and qa2-fab (apo-inward-open conformation) (340 kDa, Complex)
- Isoform 2 of phosphatidylcholine translocator abcb4 (140 kDa, Protein from Homo sapiens)
- Qa2 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Qa2 fab-fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 4b1 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7niv
Q-score: 0.382
Nosol K, Bang-Sorensen R, Irobalieva RN, Erramilli SK, Stieger B, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34385322 DOI: doi:10.1073/pnas.2106702118 ]
- Phosphatidylcholine translocator abcb4 (Complex from Homo sapiens)
- 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (782 Da, Ligand)
- Qa2 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- 4b1 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Nanodisc reconstituted human abcb4 in complex with 4b1-fab and qa2-fab (phosphatidylcholine-bound, occluded conformation) (340 kDa, Complex)
- Qa2 fab-fragment: light and heavy chain (Complex from Homo sapiens)
- Isoform 2 of phosphatidylcholine translocator abcb4 (140 kDa, Protein from Homo sapiens)
- Qa2 fab-fragment light chain (24 kDa, Protein from Homo sapiens)
- 4b1 fab-fragment light chain (25 kDa, Protein from Homo sapiens)
- 4b1 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7niw
Q-score: 0.452
Nosol K, Bang-Sorensen R, Irobalieva RN, Erramilli SK, Stieger B, Kossiakoff AA, Locher KP
PNAS (2021) 118 [ Pubmed: 34385322 DOI: doi:10.1073/pnas.2106702118 ]
- Phosphatidylcholine translocator abcb4 (Complex from Homo sapiens)
- 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (782 Da, Ligand)
- 4b1 fab-fragment heavy chain (25 kDa, Protein from Homo sapiens)
- Nanodisc reconstituted human abcb4 in complex with 4b1-fab (posaconazole-bound, inward-open conformation) (140 kDa, Complex)
- 4b1 fab-fragment: light chain (Complex from Homo sapiens)
- 4b1 fab-fragment: heavy chain (Complex from Homo sapiens)
- Phosphatidylcholine translocator abcb4 (140 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 4b1 fab-fragment light chain (23 kDa, Protein from Homo sapiens)
- Posaconazole (700 Da, Ligand)