Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajić J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ DOI: 10.1038/s41586-024-07720-6 Pubmed: 39048819 ]
Image sets:
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8qb7
Q-score: 0.323
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Resolution: 3.35 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qb9
Q-score: 0.478
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Resolution: 3.86 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qbb
Q-score: 0.404
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
- Sphingolipid long chain base-responsive protein pil1 (38 kDa, Protein from Saccharomyces cerevisiae)
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- Helical assembly of recombinant pil1 protein tubulating +pip2/-sterol lipid mixture (dopc,dope,dops,pi(4,5)p2 50:20:20:10) (Complex from Saccharomyces cerevisiae)
Resolution: 3.61 Å
EM Method: Helical reconstruction
Fitted PDBs: 8qbd
Q-score: 0.428
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
- D-myo-inositol-1,4,5-triphosphate (420 Da, Ligand)
- Sphingolipid long chain base-responsive protein pil1 (38 kDa, Protein from Saccharomyces cerevisiae)
- Helical assembly of recombinant pil1 protein tubulating +pip2/+sterol lipid mixture (dopc, dope, dops, cholesterol, pi(4,5)p2 35:20:20:15:10) (Complex from Saccharomyces cerevisiae)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
Compact state - Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8qbe
Q-score: 0.228
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Stretched state - Native eisosome lattice bound to plasma membrane microdomain
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8qbg
Q-score: 0.217
Kefauver JM, Hakala M, Zou L, Alba J, Espadas J, Tettamanti MG, Gajic J, Gabus C, Campomanes P, Estrozi LF, Sen NE, Vanni S, Roux A, Desfosses A, Loewith R
Nature (2024) 632 pp. 664-671 [ Pubmed: 39048819 DOI: doi:10.1038/s41586-024-07720-6 ]
Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7pqh
Q-score: 0.241
Prouteau M, Bourgoint C, Felix J, Bonadei L, Sadian Y, Gabus C, Savvides SN, Gutsche I, Desfosses A, Loewith R
Nat Struct Mol Biol (2023) 30 pp. 273-285 [ Pubmed: 36702972 DOI: doi:10.1038/s41594-022-00912-6 ]
- Serine/threonine-protein kinase tor2 (281 kDa, Protein from Saccharomyces cerevisiae)
- Target of rapamycin complex 1 subunit kog1,target of rapamycin complex 1 subunit kog1 (183 kDa, Protein from Saccharomyces cerevisiae)
- Target of rapamycin complex subunit lst8 (34 kDa, Protein from Saccharomyces cerevisiae)
- Torc1 organized in inhibited domains (toroid) (Complex from Saccharomyces cerevisiae)
Helical reconstruction of TOROID (TORC1 Organized in Inhibited Domains) filaments.
Prouteau M, Bourgoint C, Felix J, Bonadei L, Sadian Y, Gabus C, Savvides SN, Gutsche I, Desfosses A, Loewith R
Nat Struct Mol Biol (2023) 30 pp. 273-285 [ Pubmed: 36702972 DOI: doi:10.1038/s41594-022-00912-6 ]
- Serine/threonine-protein kinase tor2 (Protein from Saccharomyces cerevisiae)
- Target of rapamycin complex 1 subunit kog1 (Protein from Saccharomyces cerevisiae)
- Target of rapamycin complex subunit lst8 (Protein from Saccharomyces cerevisiae)
- Torc1 organized in inhibited domains (toroid) (Complex from Saccharomyces cerevisiae)