human 80S ribosome bound by a SKI2-exosome complex (60S signal subtracted)
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ Pubmed: 39385025 DOI: doi:10.1038/s41586-024-08015-6 ]
human 80S ribosome bound by a SKI2-exosome complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9g8m
Q-score: 0.405
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ Pubmed: 39385025 DOI: doi:10.1038/s41586-024-08015-6 ]
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l13a (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23a (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l24 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35a (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l17 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l21 (18 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l37a (10 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein el6 (32 kDa, Protein from Homo sapiens)
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- Exosome complex component rrp40,exosome complex component mtr3 (39 kDa, Protein from Homo sapiens)
- Large ribosomal subunit protein ul30 (29 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l4 (47 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l37 (11 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l15 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l22 (14 kDa, Protein from Homo sapiens)
- 28s ribosomal rna (1 MDa, RNA from Homo sapiens)
- Dis3-like exonuclease 1 (125 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l35 (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l34 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l39 (6 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- Ubiquitin (18 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l27a (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l38 (8 kDa, Protein from Homo sapiens)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l7a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- Human 80s ribosome bound by a ski2-exosome complex (Complex from Homo sapiens)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l36a (12 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l31 (14 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l36 (12 kDa, Protein from Homo sapiens)
- 5s ribosomal rna (38 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l32 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l26 (17 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l9 (21 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l13 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l23 (14 kDa, Protein from Homo sapiens)
- Isoform 2 of hbs1-like protein (30 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l11 (20 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l3 (46 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l19 (23 kDa, Protein from Homo sapiens)
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l30 (12 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l8 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l18a (20 kDa, Protein from Homo sapiens)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l28 (15 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l14 (23 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- Crpv-ires rna (78 kDa, RNA from Cricket paralysis virus)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- 18s ribosomal rna (602 kDa, RNA from Homo sapiens)
- Exosome complex component rrp45 (49 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l29 (17 kDa, Protein from Homo sapiens)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Ribosomal protein ul16-like (24 kDa, Protein from Homo sapiens)
- 5.8s ribosomal rna (50 kDa, RNA from Homo sapiens)
- 60s ribosomal protein l5 (34 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
80S-bound human Ski2-exosome complex
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 9g8n
Q-score: 0.41
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ DOI: doi:10.1038/s41586-024-08015-6 Pubmed: 39385025 ]
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Crpv-ires rna (13 kDa, RNA from Cricket paralysis virus)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Isoform 2 of hbs1-like protein (30 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- Dis3-like exonuclease 1 (121 kDa, Protein from Homo sapiens)
- 80s-bound human ski2-exosome complex (Complex from Homo sapiens)
- Exosome complex component rrp40 (29 kDa, Protein from Homo sapiens)
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- Exosome complex component rrp45 (49 kDa, Protein from Homo sapiens)
human 40S ribosome bound by a SKI238-exosome complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9g8o
Q-score: 0.307
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ Pubmed: 39385025 DOI: doi:10.1038/s41586-024-08015-6 ]
- Dis3-like exonuclease 1 (125 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s13 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s7 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s10 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s16 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s21 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s18 (17 kDa, Protein from Homo sapiens)
- Superkiller complex protein 3 (176 kDa, Protein from Homo sapiens)
- Human 40s ribosome bound by a ski238-exosome complex (Complex from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s27 (9 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s25 (13 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15 (17 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s29 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s5 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s8 (24 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s9 (22 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s15a (14 kDa, Protein from Homo sapiens)
- 60s ribosomal protein l41 (3 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s28 (7 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s30 (6 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s11 (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s14 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s23 (15 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s3a (30 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s17 (15 kDa, Protein from Homo sapiens)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Isoform 2 of hbs1-like protein (30 kDa, Protein from Homo sapiens)
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- 18s ribosomal rna (602 kDa, RNA from Homo sapiens)
- 40s ribosomal protein s3 (26 kDa, Protein from Homo sapiens)
- Ubiquitin (18 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s26 (13 kDa, Protein from Homo sapiens)
- Exosome complex component rrp45 (49 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 61 (33 kDa, Protein from Homo sapiens)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Crpv-ires rna (79 kDa, RNA from Cricket paralysis virus)
- 40s ribosomal protein s20 (13 kDa, Protein from Homo sapiens)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Homo sapiens)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s19 (16 kDa, Protein from Homo sapiens)
- 40s ribosomal protein sa (32 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s2 (31 kDa, Protein from Homo sapiens)
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s6 (28 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s24 (15 kDa, Protein from Homo sapiens)
- Exosome complex component rrp40 (29 kDa, Protein from Homo sapiens)
- 40s ribosomal protein s12 (14 kDa, Protein from Homo sapiens)
40S-bound human SKI2-exosome complex
Resolution: 7.0 Å
EM Method: Single-particle
Fitted PDBs: 9g8p
Q-score: 0.226
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ Pubmed: 39385025 DOI: doi:10.1038/s41586-024-08015-6 ]
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Isoform 2 of hbs1-like protein (30 kDa, Protein from Homo sapiens)
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- 40s-bound human ski2-exosome complex (Complex from Homo sapiens)
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- Exosome complex component rrp45 (49 kDa, Protein from Homo sapiens)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Crpv-ires rna (13 kDa, RNA from Cricket paralysis virus)
- Exosome complex component rrp40 (29 kDa, Protein from Homo sapiens)
- Dis3-like exonuclease 1 (121 kDa, Protein from Homo sapiens)
40S-bound human SKI238 complex in the open state (Gatekeeping module)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 9g8q
Q-score: 0.349
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ DOI: doi:10.1038/s41586-024-08015-6 Pubmed: 39385025 ]
- Wd repeat-containing protein 61 (33 kDa, Protein from Homo sapiens)
- 40s-bound human ski238 complex in the open state (gatekeeping module) (Complex from Homo sapiens)
- Superkiller complex protein 3 (176 kDa, Protein from Homo sapiens)
- Helicase ski2w (137 kDa, Protein from Homo sapiens)
human SKI7-SKI238 complex in the open state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9g8r
Q-score: 0.483
Kogel A, Keidel A, Loukeri MJ, Kuhn CC, Langer LM, Schafer IB, Conti E
Nature (2024) 635 pp. 237-242 [ Pubmed: 39385025 DOI: doi:10.1038/s41586-024-08015-6 ]
- Isoform 2 of hbs1-like protein (19 kDa, Protein from Homo sapiens)
- Superkiller complex protein 2 (107 kDa, Protein from Homo sapiens)
- Superkiller complex protein 3 (176 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 61 (33 kDa, Protein from Homo sapiens)
- Human ski7-ski238 complex in the open state (Complex from Homo sapiens)