Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Cryo-EM structure of human HCN3 channel in apo state
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8inz
Q-score: 0.526
Yu B, Lu Q, Li J, Cheng X, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y, Fu Y, Zhang J
J Biol Chem (2024) 300 pp. 107288-107288 [ DOI: doi:10.1016/j.jbc.2024.107288 Pubmed: 38636662 ]
- 4-[[(2~{s},4~{a}~{r},6~{s},8~{a}~{s})-6-[(4~{s},5~{r})-4-[(2~{s})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{h}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid (492 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Complex from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (86 kDa, Protein from Homo sapiens)
Melatonin receptor1-2-Iodomelatonin-Gicomplex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7vgy
Q-score: 0.508
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- G protein coupled to melatonin receptor (Complex from Homo sapiens)
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- N-[2-(2-iodo-5-methoxy-1h-indol-3-yl)ethyl]acetamide (358 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv16 (27 kDa, Protein from Mus musculus)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vgz
Q-score: 0.473
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (27 kDa, Protein from synthetic construct)
- N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl}propanamide (259 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Gpcr-g protein complex (Complex from Homo sapiens)
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7vh0
Q-score: 0.467
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Melatonin receptor type 1b (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl}propanamide (259 Da, Ligand)
- Melatonin receptor 2 with g peotein complex (Complex from Homo sapiens)