Structure of an orphan GPCR-G protein signaling complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wz4
Q-score: 0.523
Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y
Nat Commun (2022) 13 pp. 2375-2375 [ DOI: doi:10.1038/s41467-022-30081-5 Pubmed: 35501348 ]
- Gpr88-gi1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Gpr88-gi1 signaling complex (Complex)
- Probable g-protein coupled receptor 88 (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
Structure of the alpha2A-adrenergic receptor GoA signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ej0
Q-score: 0.426
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Scfv16 (32 kDa, Protein from Mus musculus)
- Noradrenaline (170 Da, Ligand)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ej8
Q-score: 0.482
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Scfv16 (32 kDa, Protein from Mus musculus)
- Brimonidine (292 Da, Ligand)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to dexmedetomidine
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7eja
Q-score: 0.378
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Scfv16 (32 kDa, Protein from Mus musculus)
- 4-[(1~{s})-1-(2,3-dimethylphenyl)ethyl]-1~{h}-imidazole (200 Da, Ligand)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to oxymetazoline
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ejk
Q-score: 0.453
Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y
Sci Adv (2022) 8 pp. eabj5347-eabj5347 [ DOI: doi:10.1126/sciadv.abj5347 Pubmed: 35245122 ]
- Scfv16 (32 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Alpha2a-adrenergic receptor go signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Alpha-2a adrenergic receptor (50 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Oxymetazoline (260 Da, Ligand)
- Alpha2a-adrenergic receptor go signaling complex (Complex from Homo sapiens)
Structure of the GPR88-Gi1 signaling complex bound to a synthetic ligand
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7ejx
Q-score: 0.606
Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y
Nat Commun (2022) 13 pp. 2375-2375 [ DOI: doi:10.1038/s41467-022-30081-5 Pubmed: 35501348 ]
- Gpr88-gi1 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Gpr88-gi1 signaling complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r,2r)-n-[(2s,3s)-2-azanyl-3-methyl-pentyl]-n-[4-(4-propylphenyl)phenyl]-2-pyridin-2-yl-cyclopropane-1-carboxamide (455 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Probable g-protein coupled receptor 88 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
Melatonin receptor1-2-Iodomelatonin-Gicomplex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7vgy
Q-score: 0.508
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- N-[2-(2-iodo-5-methoxy-1h-indol-3-yl)ethyl]acetamide (358 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- G protein coupled to melatonin receptor (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7vgz
Q-score: 0.473
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl}propanamide (259 Da, Ligand)
- Gpcr-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Melatonin receptor type 1a (39 kDa, Protein from Homo sapiens)
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 7vh0
Q-score: 0.467
Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y
Nat Commun (2022) 13 pp. 454-454 [ Pubmed: 35075127 DOI: doi:10.1038/s41467-022-28111-3 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- N-{2-[(8s)-1,6,7,8-tetrahydro-2h-indeno[5,4-b]furan-8-yl]ethyl}propanamide (259 Da, Ligand)
- Melatonin receptor 2 with g peotein complex (Complex from Homo sapiens)
- Scfv16 (34 kDa, Protein from Homo sapiens)
- Melatonin receptor type 1b (40 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7kh0
Q-score: 0.523
Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C
Cell Res (2021) 31 pp. 932-934 [ Pubmed: 33664408 DOI: doi:10.1038/s41422-021-00483-z ]
- Vasopressin v2 receptor (42 kDa, Protein from Homo sapiens)
- Single fab chain (scfv16) (26 kDa, Protein from Homo sapiens)
- Vasopressin v2 receptor, arg-vasopressin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Vasopressin v2 receptor complex with gs and avp (Complex)
- Nanobody 35 (Complex from Lama glama)
- Nanobody 35 (14 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Arg-vasopressin (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, single fab chain (scfv16) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (43 kDa, Protein from Homo sapiens)