Structure of the prefusion HKU5-19s Spike trimer (conformation 1)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9ea0
Q-score: 0.702
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.032 Pubmed: 39922192 ]
- Folic acid (441 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
Structure of the prefusion HKU5-19s Spike trimer (conformation 2)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9eh8
Q-score: 0.741
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.032 Pubmed: 39922192 ]
- Folic acid (441 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Linoleic acid (280 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
Merbecovirus PnNL2018B Spike glycoprotein RBD bound to the P. Nathusii ACE2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9dak
Q-score: 0.632
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Merbecovirus pnnl2018b spike glycoprotein rbd bound to the p. nathusii ace2 (Complex from Merbecovirus)
- Spike glycoprotein receptor binding domain (34 kDa, Protein from Merbecovirus)
- Ace2 (102 kDa, Protein from Pipistrellus nathusii)
- Water (18 Da, Ligand)
Structure of the HKU5-19s RBD bound to the Bos taurus ACE2 receptor
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9e0i
Q-score: 0.676
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.032 Pubmed: 39922192 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (89 kDa, Protein from Bos taurus)
- Water (18 Da, Ligand)
- Hku5-19s rbd bound to the bos taurus ace2 receptor (Complex from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9c44
Q-score: 0.535
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ Pubmed: 39478224 DOI: doi:10.1038/s41586-024-08121-5 ]
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)