Merbecovirus MOW15-22 Spike glycoprotein RBD bound to the P. davyi ACE2
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ Pubmed: 39922191 DOI: doi:10.1016/j.cell.2024.12.031 ]
- Mow15-22 rbd (34 kDa, Protein from Merbecovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pteronotus davyi ace2 ectodomain (89 kDa, Protein from Pteronotus davyi)
- Mow15-22 rbd bound to the p. davyi ace2 ectodomain (Complex from Sarbecovirus)
Structure of the prefusion HKU5-19s Spike trimer (conformation 1)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9ea0
Q-score: 0.702
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the prefusion HKU5-19s Spike trimer (conformation 2)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9eh8
Q-score: 0.741
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Merbecovirus PnNL2018B Spike glycoprotein RBD bound to the P. Nathusii ACE2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9dak
Q-score: 0.632
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Ace2 (102 kDa, Protein from Pipistrellus nathusii)
- Water (18 Da, Ligand)
- Merbecovirus pnnl2018b spike glycoprotein rbd bound to the p. nathusii ace2 (Complex from Merbecovirus)
- Spike glycoprotein receptor binding domain (34 kDa, Protein from Merbecovirus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HKU5-19s RBD bound to the Bos taurus ACE2 receptor
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9e0i
Q-score: 0.676
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Water (18 Da, Ligand)
- Hku5-19s rbd bound to the bos taurus ace2 receptor (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2 (89 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9c44
Q-score: 0.535
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ DOI: doi:10.1038/s41586-024-08121-5 Pubmed: 39478224 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)