Structure of the prefusion HKU5-19s Spike trimer (conformation 1)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9ea0
Q-score: 0.702
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the prefusion HKU5-19s Spike trimer (conformation 2)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9eh8
Q-score: 0.741
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HKU5 RBD bound to the P. abramus ACE2 receptor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9d32
Q-score: 0.564
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Angiotensin-converting enzyme (89 kDa, Protein from Pipistrellus abramus)
- Zinc ion (65 Da, Ligand)
- Hku5 rbd bound to the p. abramus ace2 receptor (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Merbecovirus PnNL2018B Spike glycoprotein RBD bound to the P. Nathusii ACE2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9dak
Q-score: 0.632
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Ace2 (102 kDa, Protein from Pipistrellus nathusii)
- Water (18 Da, Ligand)
- Merbecovirus pnnl2018b spike glycoprotein rbd bound to the p. nathusii ace2 (Complex from Merbecovirus)
- Spike glycoprotein receptor binding domain (34 kDa, Protein from Merbecovirus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HKU5-19s RBD bound to the Bos taurus ACE2 receptor
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9e0i
Q-score: 0.676
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Water (18 Da, Ligand)
- Hku5-19s rbd bound to the bos taurus ace2 receptor (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2 (89 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of P.nat ACE2 mutant in complex with MOW15-22 RBD
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8zuf
Q-score: 0.457
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme (90 kDa, Protein from Pipistrellus nathusii)
- P.nat ace2-mow15-22 rbd (Complex from Pipistrellus nathusii)
- Mow15-22 rbd (23 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)