Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9h9e
Q-score: 0.372
Hooda Y, Sente A, Judy RM, Smalinskaite L, Chew SP, Naydenova K, Malinauskas T, Hardwick SW, Chirgadze DY, Aricescu AR, Hegde RS
bioRxiv (2024) [ DOI: doi:10.1101/2024.10.28.620708 Pubmed: 39553992 ]
- Cholesterol (386 Da, Ligand)
- (7s)-4-hydroxy-n,n,n-trimethyl-9-oxo-7-[(palmitoyloxy)methyl]-3,5,8-trioxa-4-phosphahexacosan-1-aminium 4-oxide (763 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (54 kDa, Protein from Homo sapiens)
- Complex of gamma-aminobutyric acid receptor subunit alpha-1 with assembly factor nacho/tmem35a (Complex from Homo sapiens)
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
- Novel acetylcholine receptor chaperone (20 kDa, Protein from Homo sapiens)
FZD3 in complex with nanobody 9
Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza RR, Chang TH, Yi G, Duyvesteyn HME, Yu J, Lu W, Pardon E, Steyaert J, Zhu Y, Ni T, Jones EY
Nat Commun (2024) 15 pp. 7228-7228 [ DOI: doi:10.1038/s41467-024-51451-1 Pubmed: 39174501 ]
- Nanobody nb9 (14 kDa, Protein from Lama glama)
- Fzd3 nanobody nb9 complex (Cell from Homo sapiens)
- Frizzled-3 (60 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - APO
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bej
Q-score: 0.463
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bha
Q-score: 0.571
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Basmisanil (445 Da, Ligand)
- Gaba-a a5 subunit homopentamer complex called a5v3 (200 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO154513
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8bhb
Q-score: 0.587
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Water (18 Da, Ligand)
- Ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{h}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (326 Da, Ligand)
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO5211223
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bhi
Q-score: 0.557
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a receptor a5 homomer - a5v3 - ro5211223 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone (442 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - Diazepam
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhk
Q-score: 0.495
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - DMCM
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8bhm
Q-score: 0.485
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- Methyl 4-ethyl-6,7-dimethoxy-9h-pyrido[3,4-b]indole-3-carboxylate (314 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - L655708
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8bho
Q-score: 0.493
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Ethyl (7~{s})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate (341 Da, Ligand)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO7172670
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhq
Q-score: 0.498
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one (408 Da, Ligand)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)