Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8smv
Q-score: 0.572
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, Dror RO, Evers AS, Mukhopadhyay S, Manglik A
Nat Struct Mol Biol (2024) 31 pp. 667-677 [ DOI: doi:10.1038/s41594-024-01223-8 Pubmed: 38326651 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Gpr161 gs heterotrimeric complex with nb35 (Complex)
- G-protein coupled receptor 161 (59 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 161, guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM map of the full-length relaxin receptor RXFP1 in complex with heterotrimeric Gs
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Protein from Homo sapiens)
- Camelid antibody vhh fragment nb35 (Protein from Lama glama)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Protein from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex from Homo sapiens)
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7tmw
Q-score: 0.336
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC
Nat Chem Biol (2023) 19 pp. 1013-1021 [ DOI: doi:10.1038/s41589-023-01321-6 Pubmed: 37081311 ]
- Camelid antibody vhh fragment nb35 (Complex from Lama glama)
- Camelid antibody vhh fragment nb35 (17 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex of the relaxin receptor rxfp1 and heterotrimeric gs (180 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (113 kDa, Protein from Homo sapiens)
- Relaxin receptor 1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short fusion (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)