Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8vs6
Q-score: 0.577
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Transforming growth factor beta-3 proprotein (44 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- L-tgf-b3/avb8 complex (100 kDa, Complex)
- Integrin alpha-v (106 kDa, Protein from Homo sapiens)
- L-tgf-b3 (Complex from Homo sapiens)
- Avb8 complex (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrin beta-8 (71 kDa, Protein from Homo sapiens)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8vsb
Q-score: 0.521
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Transforming growth factor beta activator lrrc32 (66 kDa, Protein from Homo sapiens)
- L-tgf-b3/garp complex (180 kDa, Complex from Homo sapiens)
- Transforming growth factor beta-3 proprotein (44 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vsc
Q-score: 0.483
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Transforming growth factor beta activator lrrc32 (66 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (44 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vsd
Q-score: 0.508
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- Avb8/l-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Transforming growth factor beta activator lrrc32 (61 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (41 kDa, Protein from Homo sapiens)
- Avb8 complex (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-v heavy chain (65 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (Complex from Homo sapiens)
Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 6djp
Q-score: 0.275
Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y
Nat Struct Mol Biol (2018) 25 pp. 698-704 [ DOI: doi:10.1038/s41594-018-0093-x Pubmed: 30061598 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 8b8 light chain fab (23 kDa, Protein from Mus musculus)
- Integrin beta-8 (70 kDa, Protein from Homo sapiens)
- 68 heavy chain fab (22 kDa, Protein from Mus musculus)
- Alpha-v beta-8 integrin in complex with the fabs 68 and 8b8 (312 kDa, Complex from Homo sapiens)
- 68 light chain fab (23 kDa, Protein from Mus musculus)
- 8b8 heavy chain fab (23 kDa, Protein from Mus musculus)
- Integrin alpha-v (106 kDa, Protein from Homo sapiens)