Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8vs6
Q-score: 0.577
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ DOI: doi:10.1016/j.cell.2024.08.036 Pubmed: 39288764 ]
- L-tgf-b3 (Complex from Homo sapiens)
- Transforming growth factor beta-3 proprotein (44 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Integrin beta-8 (71 kDa, Protein from Homo sapiens)
- L-tgf-b3/avb8 complex (100 kDa, Complex)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-v (106 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Avb8 complex (Complex from Homo sapiens)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8vsb
Q-score: 0.521
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ DOI: doi:10.1016/j.cell.2024.08.036 Pubmed: 39288764 ]
- Transforming growth factor beta activator lrrc32 (66 kDa, Protein from Homo sapiens)
- L-tgf-b3/garp complex (180 kDa, Complex from Homo sapiens)
- Transforming growth factor beta-3 proprotein (44 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vsc
Q-score: 0.483
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ DOI: doi:10.1016/j.cell.2024.08.036 Pubmed: 39288764 ]
- Transforming growth factor beta activator lrrc32 (66 kDa, Protein from Homo sapiens)
- Transforming growth factor beta-1 proprotein (44 kDa, Protein from Homo sapiens)
- L-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vsd
Q-score: 0.508
Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y
Cell (2024) 187 pp. 6200- [ Pubmed: 39288764 DOI: doi:10.1016/j.cell.2024.08.036 ]
- Avb8 complex (Complex from Homo sapiens)
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- Integrin alpha-v heavy chain (65 kDa, Protein from Homo sapiens)
- Avb8/l-tgf-b1/garp complex (180 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- L-tgf-b1/garp complex (Complex from Homo sapiens)
- Transforming growth factor beta-1 proprotein (41 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Transforming growth factor beta activator lrrc32 (61 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Integrin alpha-v beta-8 in complex with the Fabs 8B8 and 68
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 6djp
Q-score: 0.275
Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y
Nat Struct Mol Biol (2018) 25 pp. 698-704 [ Pubmed: 30061598 DOI: doi:10.1038/s41594-018-0093-x ]
- Alpha-v beta-8 integrin in complex with the fabs 68 and 8b8 (312 kDa, Complex from Homo sapiens)
- Integrin alpha-v (106 kDa, Protein from Homo sapiens)
- Integrin beta-8 (70 kDa, Protein from Homo sapiens)
- 68 heavy chain fab (22 kDa, Protein from Mus musculus)
- 68 light chain fab (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 8b8 heavy chain fab (23 kDa, Protein from Mus musculus)
- 8b8 light chain fab (23 kDa, Protein from Mus musculus)