Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tbf
Q-score: 0.498
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7tca
Q-score: 0.282
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with antibody a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7tcc
Q-score: 0.268
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Light chain of antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of antibody a19-46.1 (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody a19-46.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7u0d
Q-score: 0.236
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Surface glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Ternary complex of sars-cov-2 omicron rbd in complex with antibodies b1-182.1 and a19-46.1 (Complex from Homo sapiens)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 7sg4
Q-score: 0.355
Martinez DR, Schafer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS
Sci Transl Med (2022) 14 pp. eabj7125-eabj7125 [ DOI: doi:10.1126/scitranslmed.abj7125 Pubmed: 34726473 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Dh1047 light chain (24 kDa, Protein from Homo sapiens)
- Sars-cov s protein in complex with receptor binding domain antibody dh1047 (Complex from Severe acute respiratory syndrome-related coronavirus)
- Dh1047 heavy chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7mlz
Q-score: 0.348
Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloniniyi OK, Henry AR, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Antia A, Cale EM, Chang LA, Choe M, Corbett KS, Davis RL, DiPiazza AT, Gordon IJ, Hait SH, Hermanus T, Kgagudi P, Laboune F, Leung K, Liu T, Mason RD, Nazzari AF, Novik L, O'Connell S, O'Dell S, Olia AS, Schmidt SD, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner DA, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Moore PL, Doria-Rose NA, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
Science (2021) 373 [ Pubmed: 34210892 DOI: doi:10.1126/science.abh1766 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- B1-182.1 fab heavy chain (24 kDa, Protein from Homo sapiens)
- B1-182.1 fab light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike rbd in complex with neutralizing antibody b1-182.1 (539 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7mm0
Q-score: 0.384
Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloniniyi OK, Henry AR, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Antia A, Cale EM, Chang LA, Choe M, Corbett KS, Davis RL, DiPiazza AT, Gordon IJ, Hait SH, Hermanus T, Kgagudi P, Laboune F, Leung K, Liu T, Mason RD, Nazzari AF, Novik L, O'Connell S, O'Dell S, Olia AS, Schmidt SD, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner DA, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Moore PL, Doria-Rose NA, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
Science (2021) 373 [ DOI: doi:10.1126/science.abh1766 Pubmed: 34210892 ]
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in complex with neutralizing antibody b1-182.1 (539 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- B1-182.1 fab light chain (23 kDa, Protein from Homo sapiens)
- B1-182.1 fab heavy chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 7lrs
Q-score: 0.419
Wang L, Zhou T, Zhang Y, Yang ES, Schramm CA, Shi W, Pegu A, Oloniniyi OK, Henry AR, Darko S, Narpala SR, Hatcher C, Martinez DR, Tsybovsky Y, Phung E, Abiona OM, Antia A, Cale EM, Chang LA, Choe M, Corbett KS, Davis RL, DiPiazza AT, Gordon IJ, Hait SH, Hermanus T, Kgagudi P, Laboune F, Leung K, Liu T, Mason RD, Nazzari AF, Novik L, O'Connell S, O'Dell S, Olia AS, Schmidt SD, Stephens T, Stringham CD, Talana CA, Teng IT, Wagner DA, Widge AT, Zhang B, Roederer M, Ledgerwood JE, Ruckwardt TJ, Gaudinski MR, Moore PL, Doria-Rose NA, Baric RS, Graham BS, McDermott AB, Douek DC, Kwong PD, Mascola JR, Sullivan NJ, Misasi J
Science (2021) 373 [ Pubmed: 34210892 DOI: doi:10.1126/science.abh1766 ]
- Antibody a23-58.1 light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with neutralizing antibody a789-58.1 (539 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody a23-58.1 heavy chain (24 kDa, Protein from Homo sapiens)