Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n28
Q-score: 0.385
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ Pubmed: 35319830 DOI: doi:10.1002/advs.202200063 ]
- J033 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- Alpha-d-mannopyranose (180 Da, Ligand)
- J033 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (19 kDa, Protein from Human immunodeficiency virus 1)
- Phosphate ion (94 Da, Ligand)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A complex of hiv-1 env with antibodies 3bnc117 and j033 (Complex from Homo sapiens)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7mxd
Q-score: 0.47
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ Pubmed: 35319830 DOI: doi:10.1002/advs.202200063 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Phosphate ion (94 Da, Ligand)
- J038 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- J038 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- A complex of hiv-1 env with antibodies 3bnc117 and j038 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
Structure of freshly purified SARS-CoV-2 S2P spike at pH 7.4
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7mtc
Q-score: 0.6
Olia AS, Tsybovsky Y, Chen SJ, Liu C, Nazzari AF, Ou L, Wang L, Kong WP, Leung K, Liu T, Stephens T, Teng IT, Wang S, Yang ES, Zhang B, Zhang Y, Zhou T, Mascola JR, Kwong PD
J Biol Chem (2021) 297 pp. 101127-101127 [ Pubmed: 34461095 DOI: doi:10.1016/j.jbc.2021.101127 ]
Structure of aged SARS-CoV-2 S2P spike at pH 7.4
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mtd
Q-score: 0.443
Olia AS, Tsybovsky Y, Chen SJ, Liu C, Nazzari AF, Ou L, Wang L, Kong WP, Leung K, Liu T, Stephens T, Teng IT, Wang S, Yang ES, Zhang B, Zhang Y, Zhou T, Mascola JR, Kwong PD
J Biol Chem (2021) 297 pp. 101127-101127 [ Pubmed: 34461095 DOI: doi:10.1016/j.jbc.2021.101127 ]
Structure of SARS-CoV-2 S2P spike at pH 7.4 refolded by low-pH treatment
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mte
Q-score: 0.523
Olia AS, Tsybovsky Y, Chen SJ, Liu C, Nazzari AF, Ou L, Wang L, Kong WP, Leung K, Liu T, Stephens T, Teng IT, Wang S, Yang ES, Zhang B, Zhang Y, Zhou T, Mascola JR, Kwong PD
J Biol Chem (2021) 297 pp. 101127-101127 [ Pubmed: 34461095 DOI: doi:10.1016/j.jbc.2021.101127 ]
Structure of SARS-CoV-2 spike at pH 4.5
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7jwy
Q-score: 0.612
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Water (18 Da, Ligand)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike at ph 4.5 (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Structure of SARS-CoV-2 spike at pH 4.0
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 6xlu
Q-score: 0.63
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Sars-cov-2 spike (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Consensus structure of SARS-CoV-2 spike at pH 5.5
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6xm0
Q-score: 0.583
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Sars-cov-2 spike (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6xm3
Q-score: 0.562
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Sars-cov-2 spike (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6xm4
Q-score: 0.559
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ Pubmed: 33271067 DOI: doi:10.1016/j.chom.2020.11.004 ]
- Sars-cov-2 spike (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)