Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- A12v163-b.01 heavy chain (Protein from Macaca mulatta)
- Pgt122 heavy chain (Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip gp41 (Protein from Human immunodeficiency virus 1)
- Quaternary complex of hiv-1 env bg505 ds-sosip with antibodies a12v163-b.01, vrc03 and pgt122. (630 kDa, Complex)
- Pgt122 (Complex from Homo sapiens)
- A12v163-b.01 light chain (Protein from Macaca mulatta)
- Hiv-1 env bg505 ds-sosip gp41 (Complex from Human immunodeficiency virus 1)
- Hiv-1 env bg505 ds-sosip gp120 (Protein from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- A12v163-b.01 (Complex from Macaca mulatta)
- Pgt122 light chain (Protein from Homo sapiens)
- Vrc03 light chain (Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 heavy chain (Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6ot1
Q-score: 0.429
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- 0pv-b.01 light (23 kDa, Protein from Macaca mulatta)
- 0pv-b.01 (Complex from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light (22 kDa, Protein from Homo sapiens)
- Vrc03 light (23 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- Bg505 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 heavy (25 kDa, Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip and antibodies 0pv-b.01, vrc03 and pgt122 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- Vrc03 heavy (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (Complex from Human immunodeficiency virus 1)
- 0pv-b.01 heavy (24 kDa, Protein from Macaca mulatta)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6mph
Q-score: 0.404
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- Df1w-a.01 (Complex from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Df1w-a.01 heavy chain (12 kDa, Protein from Macaca mulatta)
- Df1w-a.01 light chain (12 kDa, Protein from Macaca mulatta)
- Pgt122 (Complex from Homo sapiens)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (Complex from Human immunodeficiency virus 1)
- Df1w-a.01 fab bound to hiv-1 env bg505 ds-sosip-vrc03 fab- pgt122 fab (630 kDa, Complex)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6n1v
Q-score: 0.373
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- A12v163-a.01 (Complex from Macaca mulatta)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Quaternary complex of hiv-1 env bg505 ds-sosip with antibodies 17d4, vrc03 and pgt122. (630 kDa, Complex)
- A12v163-a.01 heavy chain (23 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp4 (Complex from Human immunodeficiency virus 1)
- A12v163-a.01 light chain (22 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- Vrc03 heavy chain (14 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6n1w
Q-score: 0.314
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Dfph-a.15 (Complex from Macaca mulatta)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Quaternary complex of hiv-1 env bg505 ds-sosip with antibodies dfph-a.15, vrc03 and pgt122. (630 kDa, Complex)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (Complex from Human immunodeficiency virus 1)
- Dfph-a.15 light chain (22 kDa, Protein from Macaca mulatta)
- Vrc03 heavy chain (14 kDa, Protein from Homo sapiens)
- Dfph-a.15 heavy chain (24 kDa, Protein from Macaca mulatta)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6nf2
Q-score: 0.405
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- Hiv-1 env bg505 ds-sosip and antibodies 0pv-c.01, vrc03 and pgt122 (Complex)
- 0pv-c.01 light chain (23 kDa, Protein from Homo sapiens)
- 0pv-c.01 (Complex from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- Vrc03 heavy chain (25 kDa, Protein from Homo sapiens)
- Pgt122 light chain (22 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- 0pv-c.01 heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- Vrc03 (Complex from Homo sapiens)
- Envelope glycoprotein gp41 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6osy
Q-score: 0.396
Kong R, Duan H, Sheng Z, Xu K, Acharya P, Chen X, Cheng C, Dingens AS, Gorman J, Sastry M, Shen CH, Zhang B, Zhou T, Chuang GY, Chao CW, Gu Y, Jafari AJ, Louder MK, O'Dell S, Rowshan AP, Viox EG, Wang Y, Choi CW, Corcoran MM, Corrigan AR, Dandey VP, Eng ET, Geng H, Foulds KE, Guo Y, Kwon YD, Lin B, Liu K, Mason RD, Nason MC, Ohr TY, Ou L, Rawi R, Sarfo EK, Schon A, Todd JP, Wang S, Wei H, Wu W, Mullikin JC, Bailer RT, Doria-Rose NA, Karlsson Hedestam GB, Scorpio DG, Overbaugh J, Bloom JD, Carragher B, Potter CS, Shapiro L, Kwong PD, Mascola JR
Cell (2019) 178 pp. 567-584.e19 [ Pubmed: 31348886 DOI: doi:10.1016/j.cell.2019.06.030 ]
- Vrc03 light (23 kDa, Protein from Homo sapiens)
- Pgt122 heavy (25 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- Hiv-1 env bg505 ds-sosip and antibodies 0pv-a.01, vrc03 and pgt122 (Complex)
- Bg505 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- 0pv-a.01 heavy (25 kDa, Protein from Homo sapiens)
- 0pv-a.01 light (23 kDa, Protein from Homo sapiens)
- 0pv-a.01 (Complex from Homo sapiens)
- Vrc03 heavy (25 kDa, Protein from Homo sapiens)
- Bg505 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc03 (Complex from Homo sapiens)
- Pgt122 light (22 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (Complex from Human immunodeficiency virus 1)
B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 6okp
Q-score: 0.468
Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West Jr AP, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ
Immunity (2019) 50 pp. 1513- [ DOI: doi:10.1016/j.immuni.2019.04.014 Pubmed: 31126879 ]
- 10-1074 light chain,10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Sf12 heavy chain,sf12 heavy chain (26 kDa, Protein from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of b41 sosip.664 trimer with three sf12 fabs and one 10-1074 fab (540 kDa, Complex)
- Sf12 fab (Complex from Homo sapiens)
- 10-1074 heavy chain,10-1074 heavy chain (26 kDa, Protein from Homo sapiens)
- B41 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Sf12 light chain,sf12 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6e5p
Q-score: 0.14
Chuang GY, Zhou J, Acharya P, Rawi R, Shen CH, Sheng Z, Zhang B, Zhou T, Bailer RT, Dandey VP, Doria-Rose NA, Louder MK, McKee K, Mascola JR, Shapiro L, Kwong PD
Structure (2019) 27 pp. 196-206.e6 [ DOI: doi:10.1016/j.str.2018.10.007 Pubmed: 30471922 ]
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex hiv-1 env bg505 ds-sosip with fab fragments of antibodies 2g12 and vrc03. (Complex from Human immunodeficiency virus 1)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (19 kDa, Protein from Human immunodeficiency virus 1)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6cde
Q-score: 0.443
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ DOI: doi:10.1038/s41591-018-0042-6 Pubmed: 29867235 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- Vfp20.01 heavy chain (22 kDa, Protein from Homo sapiens)
- Glycoprotein 41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 (Complex from Homo sapiens)
- Vfp20.01 light chain (23 kDa, Protein from Homo sapiens)
- Vfp20.01 (Complex from Homo sapiens)
- Pgt122 light chain (22 kDa, Protein from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc03 (Complex from Homo sapiens)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Pgt122 heavy chain (24 kDa, Protein from Homo sapiens)