Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7n28
Q-score: 0.385
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F
Adv Sci (2022) 9 pp. e2200063-e2200063 [ Pubmed: 35319830 DOI: doi:10.1002/advs.202200063 ]
- J033 antibody heavy chain (24 kDa, Protein from Macaca mulatta)
- Alpha-d-mannopyranose (180 Da, Ligand)
- J033 antibody light chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (19 kDa, Protein from Human immunodeficiency virus 1)
- Phosphate ion (94 Da, Ligand)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- A complex of hiv-1 env with antibodies 3bnc117 and j033 (Complex from Homo sapiens)
- 3bnc117 antibody heavy chain (24 kDa, Protein from Homo sapiens)
- 3bnc117 antibody light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM Structure of CAP256-VRC26.25 Fab bound to HIV-1 Env trimer CAP256.wk34.c80 SOSIP.RnS2
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6vtt
Q-score: 0.445
Gorman J, Chuang GY, Lai YT, Shen CH, Boyington JC, Druz A, Geng H, Louder MK, McKee K, Rawi R, Verardi R, Yang Y, Zhang B, Doria-Rose NA, Lin B, Moore PL, Morris L, Shapiro L, Mascola JR, Kwong PD
Cell Rep (2020) 31 pp. 107488-107488 [ DOI: doi:10.1016/j.celrep.2020.03.052 Pubmed: 32268107 ]
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Cryo-em structure of cap256-vrc26.25 fab bound to hiv-1 env trimer cap256.wk34.c80 sosip.rns2 (Complex)
- Hiv-1 env trimer cap256.wk34.c80 sosip.rns2 (Complex from Human immunodeficiency virus 1)
- Cap256-vrc26.25 fab (Complex from Homo sapiens)
- Vrc26.25 light chain (23 kDa, Protein from Homo sapiens)
- Vrc26.25 heavy chain (28 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of CH235UCA bound to Man5-enriched CH505.N279K.G458Y.SOSIP.664
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6uda
Q-score: 0.325
LaBranche CC, Henderson R, Hsu A, Behrens S, Chen X, Zhou T, Wiehe K, Saunders KO, Alam SM, Bonsignori M, Borgnia MJ, Sattentau QJ, Eaton A, Greene K, Gao H, Liao HX, Williams WB, Peacock J, Tang H, Perez LG, Edwards RJ, Kepler TB, Korber BT, Kwong PD, Mascola JR, Acharya P, Haynes BF, Montefiori DC
PLoS Pathog (2019) 15 pp. e1008026-e1008026 [ Pubmed: 31527908 DOI: doi:10.1371/journal.ppat.1008026 ]
- Complex of the ch235 unmutated common ancestor (uca) bound to man5-enriched ch505.n279k.g458y.sosip.664 (360 kDa, Complex from Human immunodeficiency virus 1)
- Ch505.n279k.g458y.sosip.664 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ch505.n279k.g458y.sosip.664 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch235 uca light chain fab (25 kDa, Protein from Homo sapiens)
- Ch235 uca heavy chain fab (26 kDa, Protein from Homo sapiens)
B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 6okp
Q-score: 0.468
Schoofs T, Barnes CO, Suh-Toma N, Golijanin J, Schommers P, Gruell H, West Jr AP, Bach F, Lee YE, Nogueira L, Georgiev IS, Bailer RT, Czartoski J, Mascola JR, Seaman MS, McElrath MJ, Doria-Rose NA, Klein F, Nussenzweig MC, Bjorkman PJ
Immunity (2019) 50 pp. 1513- [ DOI: doi:10.1016/j.immuni.2019.04.014 Pubmed: 31126879 ]
- 10-1074 light chain,10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Sf12 heavy chain,sf12 heavy chain (26 kDa, Protein from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of b41 sosip.664 trimer with three sf12 fabs and one 10-1074 fab (540 kDa, Complex)
- Sf12 fab (Complex from Homo sapiens)
- 10-1074 heavy chain,10-1074 heavy chain (26 kDa, Protein from Homo sapiens)
- B41 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Sf12 light chain,sf12 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)