Resolution: 4.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8s70
Q-score: 0.245
Vascon F, De Felice S, Gasparotto M, Huber ST, Catalano C, Chinellato M, Mezzetti R, Grinzato A, Filippini F, Maso L, Jakobi AJ, Cendron L
iScience (2025) 28 pp. 111726-111726 [ DOI: doi:10.1016/j.isci.2024.111726 Pubmed: 39898034 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Recombinase a (reca) assembled onto ssdna 72-mer in presence of atpgs and mg2+ (Complex)
- Ssdna (Complex from synthetic construct)
- Dna (1 kDa, DNA from synthetic construct)
- Recombinase a (reca) (Complex from Pseudomonas aeruginosa PAO1)
- Protein reca (35 kDa, Protein from Pseudomonas aeruginosa)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of Pseudomonas aeruginosa Recombinase A (RecA) in complex with LexAS125A mutant
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8s7g
Q-score: 0.392
Vascon F, De Felice S, Gasparotto M, Huber ST, Catalano C, Chinellato M, Mezzetti R, Grinzato A, Filippini F, Maso L, Jakobi AJ, Cendron L
iScience (2025) 28 pp. 111726-111726 [ DOI: doi:10.1016/j.isci.2024.111726 Pubmed: 39898034 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Ssdna (Complex from synthetic construct)
- Dna (36-mer) (10 kDa, DNA from synthetic construct)
- Protein reca (38 kDa, Protein from Pseudomonas aeruginosa)
- Recombinase a (reca) and lexa repressor (Complex from Pseudomonas aeruginosa)
- Cryo-em structure of pseudomonas aeruginosa recombinase a (reca) in complex with lexas125a mutant (Complex)
- Magnesium ion (24 Da, Ligand)
- Lexa repressor (23 kDa, Protein from Pseudomonas aeruginosa)
Maso L, Rajak E, Bang I, Koide A, Hattori T, Neel BG, Koide S
PNAS (2024) 121 pp. e2319029121-e2319029121 [ DOI: doi:10.1073/pnas.2319029121 Pubmed: 38781214 ]
- Fab r023 (Complex from Homo sapiens)
- Binary complex of fab r023 with sotorasib-conjugated kras g12c peptide (8-16) presented by class i mhc having hla-a*03:01 (92 kDa, Complex)
- R023 fab heavy chain (24 kDa, Protein from Homo sapiens)
- R023 fab light chain (23 kDa, Protein from Homo sapiens)
- Class i mhc, having hla-a*03:01, with beta-2-microglobulin (Complex from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Sotorasib-conjugated kras g12c peptide (8-16) (Complex from Homo sapiens)
- Amg 510 (bound form) (562 Da, Ligand)
- Gtpase kras, n-terminally processed (789 Da, Protein from Homo sapiens)
- Hla class i histocompatibility antigen, a alpha chain (32 kDa, Protein from Homo sapiens)
Maso L, Rajak E, Bang I, Koide A, Hattori T, Neel BG, Koide S
PNAS (2024) 121 pp. e2319029121-e2319029121 [ DOI: doi:10.1073/pnas.2319029121 Pubmed: 38781214 ]
- Sotorasib-conjugated kras g12c peptide (7-16) (Complex from Homo sapiens)
- Fab r023 (Complex from Homo sapiens)
- Binary complex of fab r023 with sotorasib-conjugated kras g12c peptide (7-16) presented by class i mhc having hla-a*03:01 (92 kDa, Complex)
- R023 fab heavy chain (24 kDa, Protein from Homo sapiens)
- R023 fab light chain (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Class i mhc, having hla-a*03:01, with beta-2-microglobulin (Complex from Homo sapiens)
- Hla class i histocompatibility antigen, a alpha chain (31 kDa, Protein from Homo sapiens)
- Amg 510 (bound form) (562 Da, Ligand)
- Gtpase kras, n-terminally processed (889 Da, Protein from Homo sapiens)
Maso L, Rajak E, Bang I, Koide A, Hattori T, Neel BG, Koide S
PNAS (2024) 121 pp. e2319029121-e2319029121 [ DOI: doi:10.1073/pnas.2319029121 Pubmed: 38781214 ]
- Sotorasib-conjugated kras g12c peptide (7-16) (Complex from Homo sapiens)
- Binary complex of fab r023 with sotorasib-conjugated kras g12c peptide (7-16) presented by class i mhc having hla-a*11:01 (92 kDa, Complex)
- Fab r023 (Complex from Homo sapiens)
- R023 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Hla-a antigen (31 kDa, Protein from Homo sapiens)
- R023 fab light chain (23 kDa, Protein from Homo sapiens)
- Beta-2-microglobulin (11 kDa, Protein from Homo sapiens)
- Amg 510 (bound form) (562 Da, Ligand)
- Gtpase kras, n-terminally processed (889 Da, Protein from Homo sapiens)
- Class i mhc, having hla-a*11:01, with beta-2-microglobulin (Complex from Homo sapiens)