Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6xeu
Q-score: 0.549
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- G protein-activated inward rectifier potassium channel 2 (39 kDa, Protein from Mus musculus)
- Potassium ion (39 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- G protein-gated inwardly rectifying potassium channel (girk2) (Complex from Mus musculus)
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6xev
Q-score: 0.52
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- G protein-activated inward rectifier potassium channel 2 (39 kDa, Protein from Mus musculus)
- Potassium ion (39 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- G protein-gated inwardly rectifying potassium channel (girk2) (Complex from Mus musculus)
CryoEM structure of apo G protein-gated inwardly rectifying potassium channel GIRK2
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA
Cell Rep (2021) 36 pp. 109619- [ DOI: doi:10.1016/j.celrep.2021.109619 ]
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC
Cell (2021) 184 pp. 983-999.e24 [ DOI: doi:10.1016/j.cell.2021.01.018 Pubmed: 33606986 ]
- Interleukin-12 subunit alpha (Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-2 (Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-1 (Protein from Homo sapiens)
- Il-12 receptor extracellular domain complex (153 MDa, Complex from Homo sapiens)
- Interleukin-12 subunit beta (Protein from Homo sapiens)
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC
Cell (2021) 184 pp. 983-999.e24 [ DOI: doi:10.1016/j.cell.2021.01.018 Pubmed: 33606986 ]
- Interleukin-23 receptor (Protein from Homo sapiens)
- Interleukin-23 subunit alpha (Protein from Homo sapiens)
- Interleukin-12 receptor subunit beta-1 (Protein from Homo sapiens)
- Interleukin-12 subunit beta (Protein from Homo sapiens)
- Il-23 receptor extracellular domain complex (153 MDa, Complex from Homo sapiens)