Human GYS1-GYG1 complex inhibited state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7q0b
Q-score: 0.569
McCorvie TJ, Loria PM, Tu M, Han S, Shrestha L, Froese DS, Ferreira IM, Berg AP, Yue WW
Nat Struct Mol Biol (2022) 29 pp. 628-638 [ Pubmed: 35835870 DOI: doi:10.1038/s41594-022-00799-3 ]
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
- Glycogenin-1 (39 kDa, Protein from Homo sapiens)
- Ternary complex of phosphorylated full-length human glycogen synthase 1 in complex with minimum region of human glycogenin-1 (350 kDa, Complex from Homo sapiens)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
Human GYS1-GYG1 complex inhibited-like state bound to glucose-6-phosphate
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7q0s
Q-score: 0.375
McCorvie TJ, Loria PM, Tu M, Han S, Shrestha L, Froese DS, Ferreira IM, Berg AP, Yue WW
Nat Struct Mol Biol (2022) 29 pp. 628-638 [ Pubmed: 35835870 DOI: doi:10.1038/s41594-022-00799-3 ]
- Ternary complex of phosphorylated full-length human glycogen synthase 1 in complex with minimum region of human glycogenin-1 (350 kDa, Complex from Homo sapiens)
- Glycogenin-1 (39 kDa, Protein from Homo sapiens)
- 6-o-phosphono-alpha-d-glucopyranose (260 Da, Ligand)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
Human GYS1-GYG1 complex activated state bound to glucose-6-phosphate
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7q12
Q-score: 0.377
McCorvie TJ, Loria PM, Tu M, Han S, Shrestha L, Froese DS, Ferreira IM, Berg AP, Yue WW
Nat Struct Mol Biol (2022) 29 pp. 628-638 [ DOI: doi:10.1038/s41594-022-00799-3 Pubmed: 35835870 ]
- 6-o-phosphono-alpha-d-glucopyranose (260 Da, Ligand)
- Ternary complex of phosphorylated full-length human glycogen synthase 1 in complex with minimum region of human glycogenin-1 (350 kDa, Complex from Homo sapiens)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
- Glycogenin-1 (39 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7q13
Q-score: 0.435
McCorvie TJ, Loria PM, Tu M, Han S, Shrestha L, Froese DS, Ferreira IM, Berg AP, Yue WW
Nat Struct Mol Biol (2022) 29 pp. 628-638 [ Pubmed: 35835870 DOI: doi:10.1038/s41594-022-00799-3 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Alpha-d-glucopyranose (180 Da, Ligand)
- Ternary complex of phosphorylated full-length human glycogen synthase 1 in complex with minimum region of human glycogenin-1 (350 kDa, Complex from Homo sapiens)
- Glycogenin-1 (39 kDa, Protein from Homo sapiens)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
- 6-o-phosphono-alpha-d-glucopyranose (260 Da, Ligand)