Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8s5l
Q-score: 0.454
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
- Cystathionine beta-synthase (60 kDa, Protein from Homo sapiens)
- Helical assembly of full-length human cystathionine beta-synthase in the basal state (Complex from Homo sapiens)
- Pyridoxal-5'-phosphate (247 Da, Ligand)
- Cystathionine beta-synthase (60 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
Resolution: 4.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8s5m
Q-score: 0.222
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Basle A, Ambrosio ALB, Dias SMG, Yue WW
Nat Commun (2024) 15 pp. 2931-2931 [ Pubmed: 38575566 DOI: doi:10.1038/s41467-024-46864-x ]
MTHFR + SAH symmetric dis-inhibited state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8qa4
Q-score: 0.536
Blomgren LKM, Huber M, Mackinnon SR, Burer C, Basle A, Yue WW, Froese DS, McCorvie TJ
Nat Commun (2024) 15 pp. 3248-3248 [ Pubmed: 38622112 DOI: doi:10.1038/s41467-024-47174-y ]
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Methylenetetrahydrofolate reductase (nadph) (75 kDa, Protein from Homo sapiens)
- Human 5,10-methylenetetrahydrofolate reductase in complex with s-adenosyl-l-homocysteine, regulatory domains (150 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
MTHFR + SAH asymmetric dis-inhibited state
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8qa5
Q-score: 0.358
Blomgren LKM, Huber M, Mackinnon SR, Burer C, Basle A, Yue WW, Froese DS, McCorvie TJ
Nat Commun (2024) 15 pp. 3248-3248 [ Pubmed: 38622112 DOI: doi:10.1038/s41467-024-47174-y ]
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Methylenetetrahydrofolate reductase (nadph) (75 kDa, Protein from Homo sapiens)
- Human 5,10-methylenetetrahydrofolate reductase in complex with s-adenosyl-l-homocysteine, regulatory domains with one catalytic domain (150 kDa, Complex from Homo sapiens)
- Flavin-adenine dinucleotide (785 Da, Ligand)
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8qa6
Q-score: 0.535
Blomgren LKM, Huber M, Mackinnon SR, Burer C, Basle A, Yue WW, Froese DS, McCorvie TJ
Nat Commun (2024) 15 pp. 3248-3248 [ DOI: doi:10.1038/s41467-024-47174-y Pubmed: 38622112 ]
- Flavin-adenine dinucleotide (785 Da, Ligand)
- Methylenetetrahydrofolate reductase (nadph) (75 kDa, Protein from Homo sapiens)
- Human 5,10-methylenetetrahydrofolate reductase in complex with s-adenosyl-l-methionine (150 kDa, Complex from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7q13
Q-score: 0.435
McCorvie TJ, Loria PM, Tu M, Han S, Shrestha L, Froese DS, Ferreira IM, Berg AP, Yue WW
Nat Struct Mol Biol (2022) 29 pp. 628-638 [ Pubmed: 35835870 DOI: doi:10.1038/s41594-022-00799-3 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Alpha-d-glucopyranose (180 Da, Ligand)
- Ternary complex of phosphorylated full-length human glycogen synthase 1 in complex with minimum region of human glycogenin-1 (350 kDa, Complex from Homo sapiens)
- Glycogenin-1 (39 kDa, Protein from Homo sapiens)
- Glycogen [starch] synthase, muscle (83 kDa, Protein from Homo sapiens)
- 6-o-phosphono-alpha-d-glucopyranose (260 Da, Ligand)