GP38-GnH-DS-Gc in the pre-fusion conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b8j
Q-score: 0.474
McFadden E, Monticelli SR, Wang A, Ramamohan AR, Batchelor TG, Kuehne AI, Bakken RR, Tse AL, Chandran K, Herbert AS, McLellan JS
Cell (2025) 188 pp. 303-315.e13 [ DOI: doi:10.1016/j.cell.2024.11.008 Pubmed: 39701101 ]
- Adi-36125 light chain (26 kDa, Protein from Homo sapiens)
- Glycoprotein c (59 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-46152 heavy chain (52 kDa, Protein from Homo sapiens)
- Adi-36125 heavy chain (51 kDa, Protein from Homo sapiens)
- Adi-46152 light chain (25 kDa, Protein from Homo sapiens)
- Gp38-gnh-ds-gc in complex with adi-46152 and adi-36125 fabs (Complex from Orthonairovirus haemorrhagiae)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Glycoprotein n (10 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Bat SARS-like Coronavirus RsSHC014 Spike Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cas
Q-score: 0.547
Tse AL, Acreman CM, Ricardo-Lax I, Berrigan J, Lasso G, Balogun T, Kearns FL, Casalino L, McClain GL, Chandran AM, Lemeunier C, Amaro RE, Rice CM, Jangra RK, McLellan JS, Chandran K, Miller EH
PLoS Pathog (2024) 20 pp. e1012704-e1012704 [ Pubmed: 39546542 DOI: doi:10.1371/journal.ppat.1012704 ]
SARS-CoV-2 spike omicron (BA.1) ectodomain trimer in complex with SC27 Fab, global refinement
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC
Cell Rep Med (2024) 5 pp. 101668-101668 [ Pubmed: 39094579 DOI: doi:10.1016/j.xcrm.2024.101668 ]
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC
Cell Rep Med (2024) 5 pp. 101668-101668 [ Pubmed: 39094579 DOI: doi:10.1016/j.xcrm.2024.101668 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8vym
Q-score: 0.476
Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
PNAS (2024) 121 pp. e2404250121-e2404250121 [ DOI: doi:10.1073/pnas.2404250121 Pubmed: 39231203 ]
- Envelope glycoprotein b (88 kDa, Protein from Human betaherpesvirus 5)
- 7h3 fab light chain (22 kDa, Protein from Homo sapiens)
- 7h3 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Soluble ectodomain of human cytomegalovirus (hcmv) glycoprotein b (gb) in the postfusion conformation in complex with 1g2 and 7h3 fabs (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1g2 fab light chain (22 kDa, Protein from Homo sapiens)
- 1g2 fab heavy chain (24 kDa, Protein from Homo sapiens)
Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
PNAS (2024) 121 pp. e2404250121-e2404250121 [ DOI: doi:10.1073/pnas.2404250121 Pubmed: 39231203 ]
- Fab 1g2 (Complex from Homo sapiens)
- Human cytomegalovirus (hcmv) glycoprotein b (gb) ectodomain (Complex from Human betaherpesvirus 5)
- Fab 7h3 (Complex from Homo sapiens)
- Soluble ectodomain of human cytomegalovirus (hcmv) glycoprotein b (gb) stabilized in a prefusion-like conformation in complex with 1g2 and 7h3 (Complex)
Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
PNAS (2024) 121 pp. e2404250121-e2404250121 [ DOI: doi:10.1073/pnas.2404250121 Pubmed: 39231203 ]
- Fab 1g2 (Complex from Homo sapiens)
- Human cytomegalovirus (hcmv) glycoprotein b (gb) ectodomain (Complex from Human betaherpesvirus 5)
- Fab 7h3 (Complex from Homo sapiens)
- Soluble ectodomain of human cytomegalovirus (hcmv) glycoprotein b (gb) stabilized in a prefusion-like conformation in complex with 1g2 and 7h3 (Complex)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8vyn
Q-score: 0.551
Sponholtz MR, Byrne PO, Lee AG, Ramamohan AR, Goldsmith JA, McCool RS, Zhou L, Johnson NV, Hsieh CL, Connors M, Karthigeyan KP, Crooks CM, Fuller AS, Campbell JD, Permar SR, Maynard JA, Yu D, Bottomley MJ, McLellan JS
PNAS (2024) 121 pp. e2404250121-e2404250121 [ DOI: doi:10.1073/pnas.2404250121 Pubmed: 39231203 ]
- Soluble ectodomain of human cytomegalovirus (hcmv) glycoprotein b (gb) stabilized in a prefusion-like conformation in complex with 1g2 and 7h3 (Complex)
- 7h3 fab light chain (22 kDa, Protein from Homo sapiens)
- 7h3 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein b (88 kDa, Protein from Human betaherpesvirus 5)
- 1g2 fab light chain (22 kDa, Protein from Homo sapiens)
- 1g2 fab heavy chain (24 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike S2 bound to Fab 54043-5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vcr
Q-score: 0.535
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe Jr JE, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS
Structure (2024) 32 pp. 1893- [ DOI: doi:10.1016/j.str.2024.08.022 Pubmed: 39326419 ]
- Trimeric s2 bound to fab 54043-5 (Complex)
- 54043-5 fab heavy chain (25 kDa, Protein from Homo sapiens)
- S2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- 54043-5 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 54043-5 (Complex from Homo sapiens)
- Spike protein s2 (65 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike omicron (BA.1) ectodomain trimer in complex with SC27 Fab, local refinement
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vif
Q-score: 0.545
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC
Cell Rep Med (2024) 5 pp. 101668-101668 [ Pubmed: 39094579 DOI: doi:10.1016/j.xcrm.2024.101668 ]
- Sc27 fab light chain (11 kDa, Protein from Homo sapiens)
- Sc27 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike omicron (ba.1) ectodomain trimer in complex with sc27 fab, global refinement (Complex)
- Sars-cov-2 spike omicron (ba.1) ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sc27 fab heavy chain (14 kDa, Protein from Homo sapiens)