Focused Refined Map BORF2-APOBEC3Bctd Complex
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS
Sci Adv (2022) 8 pp. eabm2827-eabm2827 [ Pubmed: 35476445 DOI: doi:10.1126/sciadv.abm2827 ]
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS
Sci Adv (2022) 8 pp. eabm2827-eabm2827 [ Pubmed: 35476445 DOI: doi:10.1126/sciadv.abm2827 ]
Composite Map BORF2-APOBEC3Bctd Complex
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 7rw6
Q-score: 0.533
Shaban NM, Yan R, Shi K, Moraes SN, Cheng AZ, Carpenter MA, McLellan JS, Yu Z, Harris RS
Sci Adv (2022) 8 pp. eabm2827-eabm2827 [ Pubmed: 35476445 DOI: doi:10.1126/sciadv.abm2827 ]
- Mbp-borf2 (large subunit of ebv ribonucleotide reductase with n-terminal mbp tag) (Complex from Epstein-Barr virus)
- Apobec3bctd-mychis (human apobec3b protein with c-terminal mychis tag) (Complex from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,ribonucleoside-diphosphate reductase large subunit (133 kDa, Protein from Human gammaherpesvirus 4)
- Borff2/apobec3bctd (Complex)
- Zinc ion (65 Da, Ligand)
- Dna dc->du-editing enzyme apobec-3b (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 7kbb
Q-score: 0.274
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- Hcmv pentamer (refinement focused on three of the subunits) (Complex from Human betaherpesvirus 5)
- Hcmv pentamer bound by antibodies 2-18 and 8i21 (280 kDa, Complex)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Fab 8i21 (Complex from Homo sapiens)
- 8i21 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- 8i21 fab light chain (23 kDa, Protein from Homo sapiens)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-18 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Fab 2-18 (Complex from Homo sapiens)
- 2-18 fab light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7m22
Q-score: 0.409
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Neuropilin-2 (65 kDa, Protein from Homo sapiens)
- The ectodomain of the hcmv pentamer (Complex from Human betaherpesvirus 5)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- The ectodomain of the hcmv pentamer bound by domains a1a2b1b2 of human neuropilin 2 (230 kDa, Complex)
- Calcium ion (40 Da, Ligand)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Domains a1a2b1b2 of human neuropilin 2 (Complex from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7m30
Q-score: 0.323
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ DOI: doi:10.1126/sciadv.abm2546 Pubmed: 35275718 ]
- 2-25 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 1-32 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 1-103 fab (Complex from Homo sapiens)
- 1-103 fab light chain (22 kDa, Protein from Homo sapiens)
- Hcmv pentamer (Complex from Human betaherpesvirus 5)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- 1-32 fab light chain (23 kDa, Protein from Homo sapiens)
- 1-103 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- 1-32 fab (Complex from Homo sapiens)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 2-25 fab light chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Quaternary complex of the hcmv pentamer bound by fabs 1-103, 1-32, and 2-25 (310 kDa, Complex)
- Envelope glycoprotein l (27 kDa, Protein from Human cytomegalovirus)
- 2-25 fab (Complex from Homo sapiens)