GP38-GnH-DS-Gc in the pre-fusion conformation
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b8j
Q-score: 0.474
McFadden E, Monticelli SR, Wang A, Ramamohan AR, Batchelor TG, Kuehne AI, Bakken RR, Tse AL, Chandran K, Herbert AS, McLellan JS
Cell (2025) 188 pp. 303-315.e13 [ DOI: doi:10.1016/j.cell.2024.11.008 Pubmed: 39701101 ]
- Adi-36125 light chain (26 kDa, Protein from Homo sapiens)
- Glycoprotein c (59 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-46152 heavy chain (52 kDa, Protein from Homo sapiens)
- Adi-36125 heavy chain (51 kDa, Protein from Homo sapiens)
- Adi-46152 light chain (25 kDa, Protein from Homo sapiens)
- Gp38-gnh-ds-gc in complex with adi-46152 and adi-36125 fabs (Complex from Orthonairovirus haemorrhagiae)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Glycoprotein n (10 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CCHFV GP38 bound with ADI-46143 and ADI-46158 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Adi-46158 fab (Complex from Homo sapiens)
- Adi-46143 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-46158 fab heavy chain (Protein from Homo sapiens)
- Adi-46158 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 bound with adi-46143 fab and adi-46158 fab (Complex)
- Adi-46143 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-46143 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58062 and ADI-63530 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Cchfv gp38 bound with adi-58062 fab and adi-63530 fab (Complex)
- Adi-63530 fab (Complex from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-63530 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-58062 fab light chain (Protein from Homo sapiens)
- Adi-63530 fab light chain (Protein from Homo sapiens)
- Adi-58062 fab (Complex from Homo sapiens)
- Adi-58062 fab heavy chain (Protein from Homo sapiens)
CCHFV GP38 bound with ADI-58026 and ADI-63547 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Adi-58026 fab (Complex from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 bound with adi-58026 fab and adi-63547 fab (Complex)
- Adi-63547 fab (Complex from Homo sapiens)
- Adi-58026 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-63547 fab light chain (Protein from Homo sapiens)
- Adi-63547 fab heavy chain (Protein from Homo sapiens)
CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vww
Q-score: 0.412
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Adi-58048 fab light chain (23 kDa, Protein from Homo sapiens)
- Cchfv gp38 bound with adi-46152 and adi-58048 fabs (Complex)
- Adi-46152 fab (Complex from Homo sapiens)
- Adi-58048 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Adi-46152 fab light chain (22 kDa, Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-46152 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-58048 fab (Complex from Homo sapiens)