Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin.
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7x1t
Q-score: 0.462
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ DOI: doi:10.1038/s41422-022-00646-6 Pubmed: 35352031 ]
- Mini-g alpha q protein (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Taltirelin (423 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7x1u
Q-score: 0.445
Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Res (2022) 32 pp. 858-861 [ DOI: doi:10.1038/s41422-022-00646-6 Pubmed: 35352031 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Bos taurus)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- Mini-g alpha q prtoein (28 kDa, Protein from Homo sapiens)
- The thyrotropin-releasing hormone receptor and gq heterotrimer complex (Complex from Homo sapiens)
- Endogenous peptide agonist trh (362 Da, Protein from synthetic construct)
Structure of somatostatin receptor 2 bound with SST14.
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7xat
Q-score: 0.545
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- The endogenous ligand sst14-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Structure of somatostatin receptor 2 bound with octreotide.
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7xau
Q-score: 0.49
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Octreotide (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The sst anologue octreotide bound somatostatin receptor 2 and gi heterotrimer complex (Complex from Homo sapiens)
Structure of somatostatin receptor 2 bound with lanreotide.
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7xav
Q-score: 0.514
Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C
Cell Discov (2022) 8 pp. 47-47 [ DOI: doi:10.1038/s41421-022-00405-2 Pubmed: 35595746 ]
- Somatostatin receptor type 2,largebit (63 kDa, Protein from synthetic construct)
- Lanreotide (1 kDa, Protein from synthetic construct)
- Scfv16 (32 kDa, Protein from Rattus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- The sst analogue lanreotide-bound somatostatin receptor 2 and gi heterotrimer complex. (Complex from Homo sapiens)