Cryo-EM Structure of the Prostaglandin D2 Receptor 2 Coupled to G Protein
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8xxu
Q-score: 0.432
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Pd2r2-g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8xxv
Q-score: 0.479
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- Indomethacin (357 Da, Ligand)
- Pd2r2-indomethacin-g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Prostaglandin d2 (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Human calcium-sensing receptor bound with cinacalcet in detergent
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wpg
Q-score: 0.541
Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C
Cell Res (2024) 34 pp. 169-172 [ DOI: doi:10.1038/s41422-023-00892-2 Pubmed: 37919470 ]
- Phosphate ion (94 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Tryptophan (204 Da, Ligand)
- Extracellular calcium-sensing receptor (102 kDa, Protein from Homo sapiens)
- Calcium sensing receptor dimer (Complex from Homo sapiens)
Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8wpu
Q-score: 0.49
Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C
Cell Res (2024) 34 pp. 169-172 [ DOI: doi:10.1038/s41422-023-00892-2 Pubmed: 37919470 ]
- Phosphate ion (94 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
- Casr-gq complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor,calcium-sensing receptor (120 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- G subunit q (gi2-mini-gq chimeric) (28 kDa, Protein from Homo sapiens)
- Scfv16 (31 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Structure of human inner kinetochore CCAN-DNA complex
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 7xhn
Q-score: 0.321
Tian T, Chen L, Dou Z, Yang Z, Gao X, Yuan X, Wang C, Liu R, Shen Z, Gui P, Teng M, Meng X, Hill DL, Li L, Zhang X, Liu X, Sun L, Zang J, Yao X
Cell Discov (2022) 8 pp. 90-90 [ DOI: doi:10.1038/s41421-022-00439-6 Pubmed: 36085283 ]
- Centromere protein l (39 kDa, Protein from Homo sapiens)
- Ccan-dna (Complex from Homo sapiens)
- Centromere protein p (33 kDa, Protein from Homo sapiens)
- Centromere protein t (60 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Centromere protein r (20 kDa, Protein from Homo sapiens)
- Centromere protein i (86 kDa, Protein from Homo sapiens)
- Centromere protein n (40 kDa, Protein from Homo sapiens)
- Centromere protein h (29 kDa, Protein from Homo sapiens)
- Centromere protein x (8 kDa, Protein from Homo sapiens)
- Centromere protein q (31 kDa, Protein from Homo sapiens)
- Centromere protein k (31 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Centromere protein c (107 kDa, Protein from Homo sapiens)
- Cenp-w (10 kDa, Protein from Homo sapiens)
- Centromere protein u (47 kDa, Protein from Homo sapiens)
- Centromere protein s (15 kDa, Protein from Homo sapiens)
- Centromere protein m (19 kDa, Protein from Homo sapiens)
- Centromere protein o (33 kDa, Protein from Homo sapiens)
Structure of 1:1 PAPP-A.ProMBP complex(half map)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7y5n
Q-score: 0.476
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pappalysin-1 (172 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Structure of 1:1 papp-a/prombp complex(half map) (Complex from Homo sapiens)
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
Structure of 1:1 PAPP-A.STC2 complex(half map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7y5q
Q-score: 0.438
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Structure of 1:1 papp-a/stc2 complex(half map) (Complex from Homo sapiens)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)
Structure of 2:2 PAPP-A.ProMBP comple
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 8hgg
Q-score: 0.408
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Bone marrow proteoglycan (25 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Structure of 2:2 papp-a/prombp complex (Complex from Homo sapiens)
- Pappalysin-1 (181 kDa, Protein from Homo sapiens)
Structure of 2:2 PAPP-A.STC2 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 8hgh
Q-score: 0.295
Zhong Q, Chu H, Wang G, Zhang C, Li R, Guo F, Meng X, Lei X, Zhou Y, Ren R, Tao L, Li N, Gao N, Wei Y, Qiao J, Hang J
Cell Discov (2022) 8 pp. 137-137 [ Pubmed: 36550107 DOI: doi:10.1038/s41421-022-00502-2 ]
- Structure of 2:2 papp-a/stc2 complex (Complex from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,pappalysin-1 (216 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Stanniocalcin-2 (33 kDa, Protein from Homo sapiens)