CryoEM structure of the TIR domain from AbTir in complex with 3AD
Resolution: 2.74 Å
EM Method: Helical reconstruction
Fitted PDBs: 7uxu
Q-score: 0.636
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B
Science (2022) 377 pp. eadc8969-eadc8969 [ Pubmed: 36048923 DOI: doi:10.1126/science.adc8969 ]
- Molecular chaperone tir (15 kDa, Protein from Acinetobacter baumannii)
- Filament of the abtir tir domain in complex with 3ad (Complex from Acinetobacter baumannii)
- [[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (686 Da, Ligand)
Cryo-EM structure of human SARM1 TIR domain in complex with 1AD
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643-1659.e10 [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7nak
Q-score: 0.522
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643- [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
- [[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (797 Da, Ligand)
- Human sarm1 in complex with nmn and 1ad (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7nal
Q-score: 0.501
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643- [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
- Beta-nicotinamide ribose monophosphate (335 Da, Ligand)
- Human sarm1 in complex with nmn and 1ad (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (SAM-TIR:1AD)
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643-1659.e10 [ Pubmed: 35334231 DOI: doi:10.1016/j.molcel.2022.03.007 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7knq
Q-score: 0.454
Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J
PNAS (2021) 118 [ Pubmed: 33468661 DOI: doi:10.1073/pnas.2023151118 ]
- Nad(+) hydrolase sarm1 (79 kDa, Protein from Homo sapiens)
- Octameric form of sarm1 (Complex from Homo sapiens)
Cryo-EM structure of ligand-free Human SARM1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ld0
Q-score: 0.416
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T
Neuron (2021) 109 pp. 1118- [ Pubmed: 33657413 DOI: doi:10.1016/j.neuron.2021.02.009 ]
- Homo-octameric sarm1 (Complex from Homo sapiens)
- Nad(+) hydrolase sarm1 (76 kDa, Protein from Homo sapiens)